Clozapine
0098930
Ordering Recommendation
Submit With Order
Mnemonic
CLOZAPINE
Methodology
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Performed
Sun-Sat
Reported
1-3 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.  
Collect
Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA).  
Specimen Preparation
Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).  
Remarks
 
Stability
After separation from cells: Ambient: 5 weeks; Refrigerated: 2 months; Frozen: 2 months  
Reference Interval
Effective February 19, 2013
Therapeutic Range Not well established.
Toxic Level Greater than 2000 ng/mL
Interpretive Data
Clozapine concentrations between 100 and 700 ng/mL may correlate more with clinical response; however, non-responsiveness may occur within this range. For refractory schizophrenia, 350 ng/mL of clozapine is suggested to achieve a therapeutic response. After initial therapeutic response occurs, the dose should be progressively reduced to the minimum level necessary to maintain clinical remission. The likelihood of seizures and other side effects increase with clozapine levels greater than 1200 ng/mL and/or dosages greater than 600 mg/24h. Toxic concentrations may cause hypotension, cardiac abnormalities, respiratory depression, coma and death. A toxic range is not well established in children.
Note
CPT Code(s)
80159
Components
Component Test Code*Component Chart Name
0098930Clozapine
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Cross References
  • Clozaril
  • Fazaclo
  • FazaCol
  • Froidir
  • Leponex