Quantitative Liquid Chromatography-Tandem Mass Spectrometry
This test is New York DOH approved.
Effective February 19, 2013
||Not well established.
||Greater than 2000 ng/mL
Clozapine concentrations between 100 and 700 ng/mL may correlate more with clinical response; however, non-responsiveness may occur within this range. For refractory schizophrenia, 350 ng/mL of clozapine is suggested to achieve a therapeutic response. After initial therapeutic response occurs, the dose should be progressively reduced to the minimum level necessary to maintain clinical remission. The likelihood of seizures and other side effects increase with clozapine levels greater than 1200 ng/mL and/or dosages greater than 600 mg/24h. Toxic concentrations may cause hypotension, cardiac abnormalities, respiratory depression, coma and death. A toxic range is not well established in children.