Chromium, Serum
0098830
Ordering Recommendation
Submit With Order
Mnemonic
CR S
Methodology
Quantitative Inductively Coupled Plasma-Mass Spectrometry
Performed
Tue, Thu, Sat
Reported
1-4 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and non-essential over-the-counter medications (upon the advice of their physician).  
Collect
Royal blue (no additive).  
Specimen Preparation
Centrifuge; do not allow serum to remain on cells. Transfer 2 mL serum to an ARUP Trace Element-Free Transport Tube (ARUP supply #43116). Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 0.5 mL)  
Storage/Transport Temperature
Room temperature. Also acceptable: Refrigerated or frozen.  
Unacceptable Conditions
Separator tubes. Specimens that are not separated from the red cells or clot within 6 hours.  
Remarks
 
Stability
If the specimen is drawn and stored in the appropriate container, the trace element values do not change with time.  
Reference Interval
Less than or equal to 5.0 µg/L
Interpretive Data
Serum chromium is the preferred specimen type for evaluating metal ion release from metal-on-metal joint arthroplasty. Serum chromium levels may be increased in asymptomatic patients with metal-on-metal prosthetics and should be considered in the context of the overall clinical scenario. The form of chromium greatly influences distribution. Trivalent chromium resides in the plasma and is usually not of clinical importance. Hexavalent chromium is considered highly toxic; however, chromium serum levels should not be used to assess toxic exposures to hexavalent chromium as it is predominately taken up and retained by red blood cells. Symptoms associated with chromium toxicity vary based on route of exposure and dose, and may include dermatitis, impairment of pulmonary function, gastroenteritis, hepatic necrosis, bleeding, and acute tubular necrosis.
Note
Elevated results from noncertified trace element-free tubes may be due to contamination. Elevated concentrations of trace elements in serum should be confirmed with a second specimen collected in a trace element-free tube, such as royal blue sterile tube (no additive).
CPT Code(s)
82495
Components
Component Test Code*Component Chart Name
0098830Chromium, Serum
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Cross References
  • Cr Plasma
  • Cr, Blood
  • CRS
  • serum chromium levels
  • serum metal ion concentration