B-Cell Immunodeficiency Profile (INACTIVE as of: 11/17/14. Refer to 2008901)
Ordering Recommendation
Quantitative Flow Cytometry
1-3 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Time SensitiveTime Sensitive
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Green (sodium or lithium heparin), lavender (EDTA), or pink (K2EDTA). 
Specimen Preparation
Transport 5 mL whole blood. (Min: 3 mL) 
Storage/Transport Temperature
Unacceptable Conditions
Clotted, frozen, or refrigerated specimens. Specimens older than 48 hours.
New York State Clients:
Clotted, frozen, or refrigerated specimens. Specimens in heparin that are more than 48 hours old and specimens in EDTA that are more than 30 hours old. 
Specimens must be analyzed within 48 hours of collection.
New York State Clients: 
Specimens in heparin must be analyzed within 48 hours of collection; specimens in EDTA must be analyzed within 30 hours of collection. 
Ambient: 48 hours; Refrigerated: Unacceptable; Frozen: Unacceptable
New York State Clients:
Ambient: 48 hours in heparin, 30 hours in EDTA; Refrigerated: Unacceptable; Frozen: Unacceptable. 
Reference Interval
Effective November 18, 2013
Reports include age appropriate reference intervals and interpretation
Age: 0-23 months
Age: 2 years and older
% CD1911-45 %6-23 %
% HLA-DR11-45 %8-24 %
% Total Ig4-32 %5-21 %
% IgG0-4 %0-1 %
% IgM4-32 %5-21 %
% IgD4-32 %4-19 %
% IgA0-4 %0-1 %

Interpretive Data
The B-cell Immunodeficiency Profile measures circulating B-cells (CD19), their surface immunoglobulins (Total Ig, IgG, IgD, IgM, and IgA) and a common HLA class II antigen. The percentage of lymphocytes expressing CD19, various immunoglobulin fractions and HLA-DR may be altered in certain immunologic abnormalities. For example, HLA-DR is absent on B-cells in the bare lymphocyte syndrome (MHC Class II Deficiency).

Compliance Statement A: Analyte specific reagents (ASR) are used in many laboratory tests necessary for standard medical care and generally do not require U.S. Food and Drug Administration (FDA) approval or clearance. This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions. This test should not be regarded as investigational or for research use.

CPT Code(s)
86356 x7
Component Test Code*Component Chart NameLOINC
0095834% HLA-DR32751-0
0095914% CD1920593-0
0095936% SIg Total17225-4
0095937% SIg IgM9443-3
0095938% SIg IgG9442-5
0095939% SIg IgD9441-7
0095954% SIg IgA9440-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • B-cell immunodeficiency profile
  • HLA-DR, CD19, SIG IgM, IgG, IgD, IgA and Total assessment
  • immune assessment
  • Surface Immunoglobulin Expression on B-cells