Drugs of Abuse Confirmation/Quantitation - Benzodiazepines - Serum or Plasma (INACTIVE as of 08/18/14. Refer to 2010445)
Ordering Recommendation
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
1-4 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Gray (sodium fluoride/potassium oxalate). Also acceptable: Plain red, green (sodium heparin), lavender (EDTA), or pink (K2EDTA). 
Specimen Preparation
Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 2 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 1 mL) 
Storage/Transport Temperature
Unacceptable Conditions
Separator tubes. Plasma or whole blood collected in lt. blue (sodium citrate). Specimens exposed to repeated freeze/thaw cycles. 
After separation from cells: Ambient: 1 week; Refrigerated: 2 weeks; Frozen: 3 years 
Reference Interval
Interpretive Data
Drugs covered: alprazolam, alpha-hydroxyalprazolam, clonazepam, 7-amino-clonazepam, desalkylflurazepam, 2-hydroxyethylflurazepam, diazepam, lorazepam, midazolam, nordiazepam, oxazepam, temazepam, and alpha-hydroxytriazolam.

Identification of specific drug(s) taken by specimen donor is problematic due to common metabolites, some of which are prescription drugs themselves.

Positive cutoff:
20 ng/mL

The absence of expected drug(s) and/or drug metabolite(s) may indicate non-compliance, inappropriate timing of specimen collection relative to drug administration, poor drug absorption, or limitations of testing. The concentration value must be greater than or equal to the cutoff to be reported as positive. Interpretive questions should be directed to the laboratory.

For medical purposes only; not valid for forensic use.

Compliance Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

CPT Code(s)
Component Test Code*Component Chart NameLOINC
0093301Drug Conf, Benzodiazepines, Ser/Pla42586-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • 7-Aminoclonazepam
  • Alpha-Hydroxyalprazolam
  • Alpha-Hydroxytriazolam
  • Alprax
  • Alprazolam
  • Ansilan
  • Apo-Triazo
  • Ativan
  • Centrax
  • Chlorazepate
  • Chlordiazepoxide
  • Clonazepam
  • Clonopin
  • Dalmadorm
  • Dalmane
  • Demetrin
  • Desalkylflurazepam
  • Desmethyldiazepam
  • Desoxydemoxepam
  • Diastat
  • Diazepam
  • Dormicum
  • Halcion
  • Hydroxyethylflurazepam
  • Hypnovel
  • Klonopin
  • Librium
  • Lorazepam
  • Lysanxia
  • Medazepam
  • Midazolam
  • Mono Demetrin
  • Niravam
  • Nobrium
  • Nordazepam
  • Nordiazepam
  • Novo-Clopate
  • Oxazepam
  • Pain Management
  • Paxipam
  • Pozapam
  • Prasepine
  • Prazene
  • Prazepam
  • Ravotril
  • Reapam
  • Restoril
  • Rudotel
  • Serax
  • Temazepam
  • Temesta
  • Tranxene
  • Trepidan
  • Valium
  • Valrelease
  • Versed
  • Xanax
  • Xanor