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Estrogens, Fractionated by Tandem Mass Spectrometry
0093248
Ordering Recommendation
Recommended test for evaluating endogenous estrogen status in postmenopausal women, men, or children.
Mnemonic
EST FR TMS
Methodology
Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry
Performed
Sun-Sat
Reported
1-4 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Serum separator tube, lavender (EDTA), pink (K2EDTA), or green (sodium or lithium heparin).  
Specimen Preparation
Separate serum or plasma from cells within 2 hours of collection. Transfer 0.5 mL serum or plasma to an ARUP Standard Transport Tube. (Min 0.3 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
  
Remarks
  
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 1 week; Frozen: 1 month  
Reference Interval
 
 
Test Number Components Reference Interval
0093247Estradiol, Males, Children or Postmenopausal Females by Tandem Mass Spectrometry  
 
Reference Intervals for Estradiol-​Children
Tanner Stages
I
II
III
IV and V
Males
less than 8.0 pg/mL
less than 10.0 pg/mL
1.0-​35.0 pg/mL
3.0-​35.0 pg/mL
Females
less than 56.0 pg/mL
2.0-​133.0 pg/mL
12.0-​277.0 pg/mL
2.0-​259.0 pg/mL
Age Group
7-​9
10-​12
13-​15
16-​17
Males
less than 7.0 pg/mL
less than 11.0 pg/mL
1.0-​36.0 pg/mL
3.0-​34.0 pg/mL
Females
less than 36.0 pg/mL
1.0-​87.0 pg/mL
9.0-​249.0 pg/mL
2.0-​266.0 pg/mL

 
Reference Intervals for Estradiol-​Adults
Females 18 Years and Older Males 18 years and Older
Pre-​menopausal:
Early Follicular: 30.0-​100.0 pg/mL
Late Follicular: 100.0-​400.0 pg/mL
Luteal: 50.0-​150.0 pg/mL
10.0-​42.0 pg/mL
Postmenopausal: 2.0-​21.0 pg/mL  
0093249Estrone, by Tandem Mass Spectrometry  
 
Reference Intervals for Estrone-​Children
Tanner Stages:
I
II
III
IV and V
Males
less than 7.0 pg/mL
less than 11.0 pg/mL
1.0-​31.0 pg/mL
2.0-​30.0 pg/mL
Females
less than 27.0 pg/mL
1.0-​39.0 pg/mL
8.0-​117.0 pg/mL
4.0-​109.0 pg/mL
Age Group
7-​9
10-​12
13-​15
16-​17
Males
less than 7.0 pg/mL
less than 11.0 pg/mL
1.0-​30.0 pg/mL
1.0-​32.0 pg/mL
Females
less than 20.0 pg/mL
1.0-​40.0 pg/mL
8.0-​105.0 pg/mL
4.0-​133.0 pg/mL

 
Reference Intervals for Estrone-​Adults
Females 18 Years and Older Males 18 Years and Older
Premenopausal:
Early Follicular: less than 150.0 pg/mL
Late Follicular: 100.0-​250.0 pg/mL
Luteal: less than 200.0 pg/mL
9.0-​36.0 pg/mL
Postmenopausal: 3.0-​32.0 pg/mL  
 Estrogens Total Calculation  
 
Reference Intervals of Estrogens
Tanner Stages:
I
II
III
IV and V
Males
1.0-​11.0
1.0-​19.0
3.0-​61.0
4.0-​62.0
Females
1.0-​86.0
3.0-​169.0
23.0-​351.0
8.0-​341.0
Age Group:
7-​9
10-​12
13-​15
16-​17
Males
less than 10.0
1.0-​19.0
3.0-​62.0
4.0-​64.0
Females
1.0-​48.0
2.0-​116.0
15.0-​333.0
6.0-​354.0

 
Reference Intervals of Estrogens of Adults
Females 18 Years or Older Males 18 Years or Older
Total Estrogens (estrone+ estradiol) pg/mL Total Estrogens (estrone+ estradiol) pg/mL
Pre-​menopausal:
Early Follicular: 30.0-​250.0
Late Follicular: 200.0-​650.0
Luteal: 50.0-​350.0
19.0-​69.0
Post-​menopausal: 5.0-​52.0  
Interpretive Data


See Compliance Statement B: www.aruplab.com/CS
Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
 
Note
 
CPT Code(s)
82671
Components
Component Test Code*Component Chart NameLOINC
0093247Estradiol by TMS35384-7
0093249Estrone by TMS2258-2
0093251Estrogens Total Calculation53765-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Estrone (E1) and Estradiols (E2)
  • Total Estrogens