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Chromosome Analysis, Chronic Lymphocytic Leukemia (CLL) Panel by FISH (INACTIVE as of 11/16/09: Refer to 2002295)
0092616
Ordering Recommendation
Mnemonic
FISH CLL
Methodology
Fluorescence in situ Hybridization
Performed
On request
Reported
Varies
New York DOH Approval Status
This test is New York DOH approved.
Oncology Test Request Form Recommended (ARUP form #43099)Oncology Test Request Form Recommended (ARUP form #43099)
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
One 10 mL green (sodium heparin).  Also acceptable:  3 mL of non-diluted bone marrow aspirate collected in a heparinized syringe and transferred into a green (sodium heparin). 
Specimen Preparation
 
Storage/Transport Temperature
10 mL whole blood or 3 mL bone marrow at 20-25°C. (Min: 5 mL whole blood or 1 mL bone marrow) 
Unacceptable Conditions
Frozen, clotted, or paraffin-embedded specimens. 
Remarks
It is recommended that all FISH studies be done in conjunction with routine cytogenetic analysis. (Refer to appropriate Chromosome Analysis test for order instructions).  If FISH only is requested, please submit a copy of previous cytogenetics report.  If cell pellets or dropped cytogenetic slides are not submitted, a processing fee will apply. 
Stability
Ambient: Whole Blood: 48 hours, Bone Marrow: 24 hours; Refrigerated: Unacceptable; Frozen: Unacceptable 
Reference Interval
By report
Interpretive Data


Compliance Statement C: The performance characteristics of this test were validated by ARUP Laboratories. The U.S. Food and Drug Administration (FDA) has not approved or cleared this test. However, FDA approval or clearance is currently not required for clinical use of this test. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions. ARUP is authorized under Clinical Laboratory Improvement Amendments (CLIA) and by all states to perform high-complexity testing. Counseling and informed consent are recommended for genetic testing. Consent forms are available online.

Note
Fluorescence in situ Hybridization panel is performed for CLL prognosis specific genomic abnormalities as follows:  ATM, D13S25, Trisomy 12, p53

This test must be ordered using a Cytogenetic test request form 43099 or through your ARUP interface.  Please submit the Patient History Form - Chromosome Studies with the Electronic Packing list.  The form is available on ARUP's Web site, http://www.aruplab.com/home/consent_forms.jsp.

A processing fee will be charged if this procedure is canceled at the client's request, after the test has been set up, or if the sample integrity is inadequate to allow culture growth.

RB1 has been removed.
CPT Code(s)
88271 x4 DNA probe each; 88275 x4 Chromosomal in situ hybridization 100-300 cells each; 88291 Interpretation and report - Additional CPT code modifiers may be required for procedures performed to test for oncologic or inherited disorders.
Components
Component Test Code*Component Chart NameLOINC
0092616Chromosome FISH, CLL Panel57802-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Chronic Lymphocytic Leukemia (CLL)