ZAP-70 Analysis by Flow Cytometry (Temporary Referral as of 08/05/16; INACTIVE as of 02/06/17)
Ordering Recommendation
Flow Cytometry
1-3 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Flow Cytometry Test Request Form RecommendedFlow Cytometry Test Request Form Recommended
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Green (sodium heparin). Also acceptable: Lavender (EDTA) or pink (K2EDTA). 
Specimen Preparation
Transport 5 mL whole blood. 
Storage/Transport Temperature
Room temperature. Also acceptable: Refrigerated. Specimen should be received within 24 hours of collection for optimal viable testing. 
Unacceptable Conditions
Frozen specimens. Clotted or hemolyzed specimens. Specimens greater than 48 hours old. 
Prior diagnosis of CLL is required. Provide CBC results and Wright's stained smear, if available. 
Ambient: 24 hours; Refrigerated: 48 hours; Frozen: Unacceptable 
Reference Interval
By report
Interpretive Data
ZAP-70 results should not be used for diagnostic purposes, but may help in the clinical management of patients with established diagnoses of chronic lymphocytic leukemia. Results of this test should always be correlated with morphologic and clinical information.

Compliance Statement A: Analyte specific reagents (ASR) are used in many laboratory tests necessary for standard medical care and generally do not require U.S. Food and Drug Administration (FDA) approval or clearance. This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions. This test should not be regarded as investigational or for research use.

CPT Code(s)
88184; 88185 x2; 88187
Component Test Code*Component Chart NameLOINC
0092386ZAP-70 Analysis46722-5
0092387CD19 + Lymphocytes8117-4
0092388CD5 + CD19 - Lymphocytes
0092389CD5 + CD19 + Lymphocytes8131-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Zeta Associated Protein
  • Chronic Lymphocytic Leukemia Prognosis
  • CLL Prognosis
  • ZAP 70
  • ZAP-70 in B-CLL ( Chronic Lymphocytic Leukemia) Prognosis