Carbamazepine Epoxide and Total
Ordering Recommendation
Submit With Order
Quantitative Liquid Chromatography-Tandem Mass Spectrometry/Quantitative Enzyme Multiplied Immunoassay Technique
Mon, Thu
1-5 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.  
Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA).  
Specimen Preparation
Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)  
Storage/Transport Temperature
Unacceptable Conditions
Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).  
After separation from cells: Ambient: 48 hours; Refrigerated: 6 days; Frozen: 1 month  
Reference Interval
Effective February 19, 2013
Available Separately Components Therapeutic Range
No Carbamazepine-​10, 11 Epoxide Not well established
Toxic: Greater than 15.0 µg/mL
No Total Carbamazepine Therapeutic Range: 4.0-​12.0 µg/mL
Toxic: Greater than 20.0 µg/mL
Interpretive Data
A proposed therapeutic range is 0.4-4 µg/mL. The metabolite, Carbamazepine-10, 11-Epoxide, has anticonvulsant activity to the parent drug.

See Compliance Statement B:
CPT Code(s)
80156; 80299
Component Test Code*Component Chart Name
0090616Carbamazepine, Total
0098427Carbamazepine 10-11 Epoxide
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Cross References
  • 11 Epoxide
  • Atretol
  • Biston
  • Calepsin
  • Carbamazepine - 10,11 Epoxide, Serum or Plasma
  • Carbamazepine and Epoxide Metabolite
  • Carbamazepine Metabolite
  • Carbamazepine-10
  • Carbatrol
  • Epimaz
  • Epitol
  • Epitrol
  • Epoxide 10, 11
  • Equetro
  • Finlepsin
  • Sirtal
  • Tegretol, Metabolite
  • Telesmin