Carbamazepine Epoxide and Total
Ordering Recommendation
Optimize drug therapy and monitor patient adherence.
Quantitative Liquid Chromatography-Tandem Mass Spectrometry/Quantitative Enzyme Multiplied Immunoassay Technique
Mon, Thu
1-5 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.  
Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA).  
Specimen Preparation
Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)  
Storage/Transport Temperature
Unacceptable Conditions
Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).  
After separation from cells: Ambient: 48 hours; Refrigerated: 6 days; Frozen: 1 month  
Reference Interval
Effective February 19, 2013
Available Separately Components Therapeutic Range
No Carbamazepine-​10, 11 Epoxide Not well established
Toxic:  Greater than 15.0 µg/mL
No Total Carbamazepine Therapeutic Range: 4.0-​12.0 µg/mL
Toxic:  Greater than 20.0 µg/mL
Interpretive Data
A proposed therapeutic range is 0.4-4 µg/mL. The metabolite, Carbamazepine-10, 11-Epoxide, has anticonvulsant activity to the parent drug.

Compliance Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
CPT Code(s)
80156; 80299
Component Test Code*Component Chart NameLOINC
0090616Carbamazepine, Total3432-2
0098427Carbamazepine 10-11 Epoxide9415-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • 11 Epoxide
  • Atretol
  • Biston
  • Calepsin
  • Carbamazepine-10,11 Epoxide, Serum or Plasma
  • Carbamazepine and Epoxide Metabolite
  • Carbamazepine Metabolite
  • Carbamazepine-10
  • Carbatrol
  • Epimaz
  • Epitol
  • Epitrol
  • Epoxide 10, 11
  • Equetro
  • Finlepsin
  • Sirtal
  • Tegretol, Metabolite
  • Telesmin