Opiates, Urine, Quantitative
Ordering Recommendation

Preferred test to follow-up presumptive results. For general screening, Opiates, Urine Screen with Reflex to Quantitation (2005093) is preferred.

Quantitative Liquid Chromatography-Tandem Mass Spectrometry
1-4 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Random urine.  
Specimen Preparation
Transfer 0.5 mL with no additives or preservatives urine to an ARUP Standard Transport Tube. (Min: 0.3 mL)  
Storage/Transport Temperature
Room temperature.  
Unacceptable Conditions
Specimens exposed to repeated freeze/thaw cycles.  
Ambient: 1 week; Refrigerated: 1 month; Frozen: 3 years  
Reference Interval
Effective August 17, 2015
Drugs CoveredCutoff Concentrations
Codeine20 ng/mL
Morphine20 ng/mL
6-acetylmorphine10 ng/mL
Hydrocodone20 ng/mL
Norhydrocodone20 ng/mL
Hydromorphone20 ng/mL
Oxycodone20 ng/mL
Noroxycodone20 ng/mL
Oxymorphone20 ng/mL
Noroxymorphone20 ng/mL

Interpretive Data
Methodology: Quantitative Liquid Chromatography-Tandem Mass Spectrometry

Positive cutoff:
20 ng/mL except as specified below:
6-acetylmorphine10 ng/mL

For medical purposes only; not valid for forensic use.

Identification of specific drug(s) taken by specimen donor is problematic due to common metabolites, some of which are prescription drugs themselves. The absence of expected drug(s) and/or drug metabolite(s) may indicate non-compliance, inappropriate timing of specimen collection relative to drug administration, poor drug absorption, diluted/adulterated urine, or limitations of testing. All drug analytes covered are in the non-glucuronidated (free) forms. The concentration value must be greater than or equal to the cutoff to be reported as positive. A very small amount of an unexpected drug analyte in the presence of a large amount of an expected drug analyte may reflect pharmaceutical impurity. Interpretive questions should be directed to the laboratory.

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
CPT Code(s)
80361; 80365 (Alt code: G0480)
Component Test Code*Component Chart NameLOINC
2005092Hydrocodone, Urn, Quant3681-4
2005098Oxycodone, Urn, Quant11246-6
2005099Oxymorphone, Urn, Quant19648-5
2005222Hydromorphone, Urn, Quant9835-0
2005223Codeine, Urn, Quant3508-9
2005224Morphine, Urn, Quant3831-5
20052256-acetylmorphine, Urn, Quant19593-3
2006968Noroxycodone, Urn, Quant10975-1
2006969Noroxymorphone, Urn, Quant
2008515Norhydrocodone, Urn, Quant61422-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • 6-Acetylmorphine
  • 6-AM
  • 6-MAM
  • Anexsia
  • Avinza
  • Codeine
  • Combunox
  • Depalgos
  • DepoDur
  • Diacetylmorphine
  • Diamorphine
  • Dicodid
  • Dihydromorphinone
  • Dilaudid
  • Dimorphone
  • Drocode
  • Duodin
  • Duramorph
  • Endocet
  • Exalgo
  • Heroin
  • Histinex
  • Hycet
  • Hycodan
  • Hycomine
  • Hycotuss
  • Hydrococet
  • Hydrocodone
  • Hydromet
  • Hydromorphone
  • Hydrovo
  • Kadian
  • Kolikodol
  • Laudicon
  • Loracet
  • Lortab
  • Mercodinone
  • Methylmorphine
  • Morphine
  • MS Contin
  • MS-Contin
  • Norco
  • Novahistex
  • Numorphan
  • Numorphone
  • Opana
  • Opium
  • Oramorph
  • Orthoxycol
  • Oxycodone
  • Oxymorphone
  • Pain Management
  • Pain Management, Opiates Expanded, Quantitative, with medMATCH, Urine
  • Pain Management, Oxycodone, Quantitative, with medMATCH, Urine
  • Palladone
  • Paracodeine
  • Paragoric
  • Parzone
  • Percocet
  • Percodan
  • Roxanol
  • Roxicet
  • Roxicodone
  • Roxiprin
  • Symtan
  • Synkonin
  • Targin
  • Tussionex
  • Tylox
  • Vicodin
  • Vicoprofen
  • Zydone