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Mycophenolic Acid (INACTIVE as of 05/19/14:  Refer to 2010359)
0090213
Ordering Recommendation
Mnemonic
MPA
Methodology
High Performance Liquid Chromatography
Performed
Sun-Sat
Reported
1-2 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration. 
Collect
Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA). 
Specimen Preparation
Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL) 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution). 
Remarks
 
Stability
After separation from cells: Ambient: 6 weeks; Refrigerated: 6 weeks; Frozen: 11 months 
Reference Interval
Effective February 19, 2013
Therapeutic RangeNot well established
Toxic LevelGreater than 25.0 µg/mL

Interpretive Data
A proposed therapeutic range is 1.0-3.5 µg/mL for a 2 g/day dose. A 3 g/day dose may have plasma concentrations up to 5.0 µg/mL.Trough concentrations between 2.0 and 4.0 µg/mL have been suggested to maximize efficacy and minimize adverse effects. Adverse effects of toxicity include abdominal pain, peripheral edema, cardiac abnormalities, hypertension and electrolyte disturbances.

Note
CPT Code(s)
80180
Components
Component Test Code*Component Chart NameLOINC
0090213Mycophenolic Acid by HPLC-MS/MS55806-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Cellcept(TM)
  • CellCept(TM) MPA
  • Mofetil Ester
  • MPA-G
  • Mycophenolate
  • Mycophenolate Mofetil
  • Mycophenolic Acid Glucuronide
  • Myfortic(TM)