Amiodarone and Metabolite
0090161
Ordering Recommendation
Submit With Order
Mnemonic
AMIOD
Methodology
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Performed
Mon-Fri
Reported
1-4 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Timing of specimen collection: Pre-dose (trough) draw - at steady state concentration.  
Collect
Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA).  
Specimen Preparation
Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Amber Transport Tube. (Min: 0.5 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).  
Remarks
 
Stability
After separation from cells: Ambient: 1 month; Refrigerated: 6 weeks; Frozen: 6 weeks  
Reference Interval
Effective February 19, 2013
Therapeutic Range Total (amiodarone and metabolite): 0.5-​2.0 µg/mL
Toxic Level Greater than 3.0 µg/mL
Interpretive Data
Toxic concentrations may exacerbate arrhythmias, cause liver and lung toxicity, and thyroid dysfunction. The concentration of desmethylamiodarone, an active major metabolite, is also reported, but no therapeutic range is established. At steady-state, the metabolite concentration is similar to the amiodarone concentration.
Note
CPT Code(s)
80299
Components
Component Test Code*Component Chart Name
0090162Amiodarone
0090163N-Desethyl-Amiodarone
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Cross References
  • Cordarone
  • Nexterone
  • Pacerone