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Diazepam and Nordiazepam
0090076
Ordering Recommendation
Optimize drug therapy and monitor patient adherence.
Mnemonic
DIAZ
Methodology
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Performed
Tue, Fri
Reported
1-5 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration  
Collect
Gray (Potassium Oxalate/Sodium Fluoride). Also acceptable: Plain Red, Green (Sodium Heparin), Lavender (K2 or K3EDTA) or pink (K2EDTA).  
Specimen Preparation
Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 2 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 1 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Gel separator tubes. Plasma or whole blood collected in light blue (sodium citrate). Hemolyzed specimens.  
Remarks
 
Stability
After separation from cells: Ambient: 1 week; Refrigerated: 2 weeks; Frozen: 3 years (Avoid repeated freeze/thaw cycles)  
Reference Interval
Dose-Related Range:
Test Number
Components
Dose-Related Range
 DiazepamEffective November 16, 2015
200-1000 ng/mL - Based on normal dosage amounts
 NordiazepamEffective November 16, 2015
100-1500 ng/mL - Based on normal dosage amounts
Toxic: Greater than 2500 ng/mL

Interpretive Data
Adverse effects may include drowsiness, fatigue, ataxia and muscle weakness.


Note
CPT Code(s)
80346 (Alt code: G0480)
Components
Component Test Code*Component Chart NameLOINC
0090075Diazepam3548-5
0090195Nordiazepam3537-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Benzodiazepines
  • Clorazepate
  • Diastat
  • Diazemuls
  • Diazepam and Metabolite
  • Nordiazepam
  • Stesolid
  • T-Quil
  • Tranxene
  • Valium
  • Valrelease
  • Zetran