Hepatocellular Carcinoma Tumor Marker Panel
0081326
Ordering Recommendation
Acceptable panel for surveillance and monitoring of hepatocellular carcinoma.
Mnemonic
HEP CAR
Methodology
Quantitative Liquid Chromatography/Immunoassay
Performed
Refer to individual components
Reported
3-6 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Plain red or serum separator tube.  
Specimen Preparation
Allow specimen to clot completely at room temperature. Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Plasma  
Remarks
  
Stability
After separation from cells: Ambient: 8 hours; Refrigerated: 5 days; Frozen: 3 months (avoid repeated freeze/thaw cycles)  
Reference Interval
 
 
Test Number Components Reference Interval
 Alpha Fetoprotein Total 0-​15 ng/mL
 Alpha Fetoprotein L3 Percent 0-​9.9 percent
0081312Des-​gamma-​carboxy Prothrombin Effective August 20, 2012

0.0 -​ 7.4 ng/mL
Interpretive Data
The µTASWako method is used. Results obtained with different assay methods or kits cannot be used interchangeably.

The AFP-L3 Percent assay is intended as a risk assessment for the development of hepatocellular carcinoma in patients with chronic liver diseases.
Patients with elevated serum AFP-L3 percent should be more intensely evaluated for evidence of hepatocellular carcinoma since elevated values have been shown to be associated with a seven-fold increase in the risk for developing hepatocellular carcinoma within 21 months. For pregnant females, the result is not interpretable as a tumor marker.

The des-gamma-carboxy prothrombin (DCP) assay is intended as a risk assessment for the development of hepatocellular carcinoma in patients with chronic liver diseases. Elevated DCP values have been shown to be associated with an increased risk for developing hepatocellular carcinoma. Patients with elevated serum DCP should be more intensely evaluated for evidence of hepatocellular carcinoma.  
Note
 
CPT Code(s)
82107; 83951
Components
Component Test Code*Component Chart Name
0081207Alpha Fetoprotein Total
0081209Alpha Fetoprotein L3 Pct
0081327Des-gamma-carboxy Prothrombin
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • AFP
  • AFP-L3%
  • Alpha Fetoprotein
  • Alpha Fetoprotein, Total and L3 Percent Tumor Marker
  • Alpha-Fetoprotein (AFP) L3% and Total
  • Alpha-fetoprotein, Total
  • DCP
  • Des-Gamma-Carboxy Prothrombin Tumor Marker
  • PIVKA-II
  • Total AFP