Amino Acids Quantitative, Plasma (INACTIVE as of 02/18/14. Refer to 2009389).
Ordering Recommendation
Ion Exchange Chromatography
2-5 days
New York DOH Approval Status
This test is New York DOH approved.
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Adults: Fasting specimen preferred.
Infants and children: Draw specimen prior to feeding or 2-3 hours after a meal. 
Green (sodium or lithium heparin). 
Specimen Preparation
Separate plasma from cells ASAP or within 2 hours of collection. Avoid transferring buffy coat material. Transfer 0.5 mL plasma to an ARUP Standard Transport Tube and freeze immediately. (Min: 0.25 mL) 
Storage/Transport Temperature
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered. 
Unacceptable Conditions
Hemolyzed specimens. 
Clinical information is needed for appropriate interpretation. Additional required information includes age, gender, diet (e.g., TPN therapy), drug therapy, and family history. Biochemical Genetics Patient History Form is available on the ARUP Web site at or by contacting ARUP Client Services. 
After separation from cells: Ambient: Unacceptable; Refrigerated: 24 hours; Frozen: 1 month 
Reference Interval
0-11 months
1 year and older
0-11 months
1 year and older
Alanine200-600 µmol/L240-600 µmol/LIsoleucine20-130 µmol/L30-130 µmol/L
Allo-isoleucineNone DetectedNone DetectedLeucine40-230 µmol/L60-230 µmol/L
Arginine20-160 µmol/L40-160 µmol/LLysine60-250 µmol/L80-250 µmol/L
Aspartic Acid0-40 µmol/L0-20 µmol/LMethionine10-60 µmol/L17-53 µmol/L
Citrulline6-60 µmol/L10-60 µmol/LOrnithine20-135 µmol/L20-135 µmol/L
Cystine7-70 µmol/L7-70 µmol/LPhenylalanine30-100 µmol/L30-80 µmol/L
Glutamic Acid10-190 µmol/L10-120 µmol/LProline110-500 µmol/L110-500 µmol/L
Glutamine410-960 µmol/L410-700 µmol/LSerine90-250 µmol/L60-200 µmol/L
Glycine220-520 µmol/L140-490 µmol/LTaurine25-160 µmol/L25-80 µmol/L
Histidine40-120 µmol/L50-130 µmol/LThreonine50-300 µmol/L60-220 µmol/L
HomocystineNone DetectedNone DetectedTyrosine30-140 µmol/L30-120 µmol/L
Hydroxyproline6-90 µmol/L6-50 µmol/LValine110-300 µmol/L140-350 µmol/L

Interpretive Data

Compliance Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Common indications for amino acid testing include clinical situations such as: 1) acute life-threatening episode, 2) failure to thrive, 3) recurrent vomiting, 4) neurological deterioration, 5) hyperammonemia, 6) lethargy, 7) metabolic acidosis, and 8) testing or following therapy for a specific inborn error of metabolism (PKU, MSUD, tyrosinemia, etc.).  Listing of clinical information is particularly important for appropriate interpretation.
CPT Code(s)
Component Test Code*Component Chart NameLOINC
0080010Alanine, Plasma20636-7
0080025Arginine, Plasma20637-5
0080035Aspartic Acid, Plasma20639-1
0080083Citrulline, Plasma20640-9
0080140Glutamine, Plasma20643-3
0080150Glutamic Acid, Plasma20642-5
0080155Glycine, Plasma20644-1
0080160Histidine, Plasma20645-8
0080170Hydroxyproline, Plasma20647-4
0080185Isoleucine, Plasma20648-2
0080205Leucine, Plasma20649-0
0080210Lysine, Plasma20650-8
0080225Methionine, Plasma20651-6
0080245Ornithine, Plasma20652-4
0080265Phenylalanine, Plasma14875-9
0080295Proline, Plasma20655-7
0080335Serine, Plasma20656-5
0080345Taurine, Plasma20657-3
0080350Threonine, Plasma20658-1
0080356Tyrosine, Plasma20660-7
0080370Valine, Plasma20661-5
0080715Homocystine, Plasma20646-6
0080717Allo-isoleucine, Plasma22670-4
0080953Amino Acids, Plasma Interpretation13500-4
0099865Cystine, Plasma22672-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Allo-Isoleucine
  • Argininosuccinic Acid (ASA)
  • Branched Chain Amino Acids
  • Cystine
  • Free Homocystine
  • Glycine
  • Quantitative Plasma and Urinary Amino Acids