Porphyrins, Total, Plasma or Serum
0080429
Ordering Recommendation
Monitor porphyria cutanea tarda (PCT). Confirm diagnosis of suspected variegate porphyria (VP), erythropoietic protoporphyria (EPP).
Mnemonic
POR S
Methodology
Quantitative Fluorometry
Performed
Sun, Tue, Thu
Reported
1-4 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Green (heparin), lavender (EDTA), or plain red  
Specimen Preparation
CRITICAL: Protect from light during collection, storage, and shipment.  Separate plasma or serum from cells within 1 hour of collection. Transfer 2 mL plasma or serum to an ARUP Amber Transport Tube. (Min: 1 mL)  
Storage/Transport Temperature
Frozen.  
Unacceptable Conditions
Body fluids other than plasma or serum. Frozen whole blood. Hemolyzed specimens.  
Remarks
 
Stability
After separation from cells: Ambient: Unacceptable; Refrigerated: 4 days; Frozen: 1 month  
Reference Interval
0-15 nmol/L  
Interpretive Data
 
Note
Useful for evaluation of cutaneous photosensitivity to rule out porphyrin disorders, particularly erythropoietic protoporphyria. Urine is the best specimen for evaluation of suspected porphyria cutanea tarda (PCT), but monitoring of PCT with plasma or serum is an acceptable practice. Evaluation of neurologic and/or psychiatric symptoms associated with suspected acute porphyria (such as acute intermittent porphyria) requires Porphobilinogen (PBG), Urine (ARUP test code 0080260).

Specimens from patients with suspected erythropoietic protoporphyria should be carefully protected from exposure to light.
Protoporphyrin is extremely light sensitive, whereas uroporphyrin and coproporphyrin are much less sensitive.
CPT Code(s)
84311
Components
Component Test Code*Component Chart NameLOINC
0080433Porphyrins, Total, Plasma/Serum33311-2
0084037Porphyrins, Total, Plasma/Serum, Interp.14883-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Coproporphyrin
  • Protoporphyrin
  • Variegate Porphyria Porphyrin
  • VP Porphyrin