Alpha Fetoprotein, Serum (Tumor Marker)
0080428
 
Ordering Recommendation
Surveillance and monitoring in hepatocellular carcinoma; test is less specific than one which includes AFP-L3 isoform.
Mnemonic
AFP TM
Methodology
Quantitative Chemiluminescent Immunoassay
Performed
Sun-Sat
Reported
Within 24 hours
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
 
Collect
Plain red or serum separator tube.  
Specimen Preparation
Allow specimen to clot completely at room temperature. Separate serum from cells within 4 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.2 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
CSF (refer to Alpha Fetoprotein, CSF (Tumor Marker), ARUP test code 0020729) or plasma. Grossly hemolyzed specimens.  
Remarks
 
Stability
After separation from cells: Ambient: 24 hours; Refrigerated: 1 week; Frozen: 1 year  
Reference Interval
Effective February 19, 2013
Age Male Female
0-​13 days 5,000-​105,000 ng/mL 5,000-​105,000 ng/mL
14-​30 days 300-​60,000 ng/mL 300-​60,000 ng/mL
1 month 100-​10,000 ng/mL 100-​10,000 ng/mL
2 months 40-​1,000 ng/mL 40-​1,000 ng/mL
3 months 11-​300 ng/mL 11-​300 ng/mL
4 months 5-​200 ng/mL 5-​200 ng/mL
5 months 0-​90 ng/mL 0-​90 ng/mL
6-​11 months 0-​90 ng/mL 0-​99 ng/mL
1 year 0-​19 ng/mL 0-​36 ng/mL
2 years 0-​12 ng/mL 0-​12 ng/mL
3-​6 years 0-​5 ng/mL 0-​5 ng/mL
7 years and older 0-​9 ng/mL 0-​9 ng/mL
Interpretive Data
The Beckman Coulter Access DxI AFP method is used. Results obtained with different assay methods or kits cannot be used interchangeably. AFP is a valuable aid in the management of nonseminomatous testicular cancer patients when used in conjunction with information available from the clinical evaluation and other diagnostic procedures. Increased AFP concentrations have also been observed in ataxia telangiectasia, hereditary tyrosinemia, primary hepatocellular carcinoma, teratocarcinoma, gastrointestinal tract cancers with and without liver metastases, and in benign hepatic conditions such as acute viral hepatitis, chronic active hepatitis, and cirrhosis. The result cannot be interpreted as absolute evidence of the presence or absence of malignant disease. The result is not interpretable as a tumor marker in pregnant females.
Note
Adult males and nonpregnant females: 0.0-9.0 ng/mL
CPT Code(s)
82105
Components
Component Test Code*Component Chart Name
0080428Alpha Fetoprotein Tumor Marker
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, contact interface support at interface.support@aruplab.com.
Cross References
  • AFP
  • AFP Abdominal Fluid
  • AFP Ascites Fluid
  • AFP Paracentesis Fluid
  • Alpha-Fetoprotein