Initial test for the diagnosis and monitoring of neuroblastoma. Should be ordered concurrently with Homovanillic Acid (HVA), Urine (0080422).
- Patient Preparation
- Abstain from medications for 72 hours prior to collection.
- Collect
- 24-hour or random urine. Refrigerate 24-hour specimens during collection.
- Specimen Preparation
- Transfer 4 mL aliquot from a well-mixed 24-hour or random collection to an ARUP Standard Transport Tube. (Min: 1 mL) Record total volume and collection time interval on transport tube and test request form.
- Storage/Transport Temperature
- Refrigerated.
- Unacceptable Conditions
- Specimen types other than urine.
- Remarks
- Stability
- Ambient: Unacceptable; Refrigerated: 1 week; Frozen: 2 weeks
Components | Reference Interval | |
---|---|---|
Vanillylmandelic Acid - per 24h | 18 years and older | 0.0-7.0 mg/d |
The VMA-to-creatinine ratio will be reported when the patient is under 18 years, the urine collection is random or other than 24 hours, or the urine volume is less than 400 mL/24 hours | ||
Vanillylmandelic Acid - ratio to CRT | 0-2 years 3-5 years 6-17 years 18 years and older | 0-27 mg/g CRT 0-13 mg/g CRT 0-9 mg/g CRT 0-6 mg/g CRT |
Creatinine, Urine - per 24h | Male 3-8 years: 140-700 mg/d 9-12 years: 300-1300 mg/d 13-17 years: 500-2300 mg/d 18-50 years: 1000-2500 mg/d 51-80 years: 800-2100 mg/d 81 years and older: 600-2000 mg/d | Female 3-8 years: 140-700 mg/d 9-12 years: 300-1300 mg/d 13-17 years: 400-1600 mg/d 18-50 years: 700-1600 mg/d 51-80 years: 500-1400 mg/d 81 years and older: 400-1300 mg/d |
Medications that may interfere with catecholamines and their metabolites include amphetamines and amphetamine-like compounds, appetite suppressants, bromocriptine, buspirone, caffeine, chlorpromazine, clonidine, disulfiram, diuretics (in doses sufficient to deplete sodium), epinephrine, glucagon, guanethidine, histamine, hydrazine derivatives, imipramine, levodopa (L-dopa, Sinemet®), lithium, MAO inhibitors, melatonin, methyldopa (Aldomet®), morphine, nitroglycerin, nose drops, propafenone (Rythmol), radiographic agents, rauwolfia alkaloids (Reserpine), tricyclic antidepressants, and vasodilators. The effects of some drugs on catecholamine metabolite results may not be predictable.
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0020207 | Creatinine, Urine - per volume | 2161-8 |
0020208 | Creatinine, Urine - per 24h | 2162-6 |
0080401 | Vanillylmandelic Acid - per 24h | 3122-9 |
0080402 | Vanillylmandelic Acid Interpretation | 50948-9 |
0081306 | Vanillylmandelic Acid - per volume | 26706-2 |
0081341 | Vanillylmandelic Acid - ratio to CRT | 30571-4 |
0097110 | Total Volume | 19153-6 |
0097111 | Hours Collected | 30211-7 |
- 3-Methoxy-4-Hydroxy-Mandelic Acid
- 3-Methoxy-4-Hydroxymandelic Acid
- 4-Hydroxy-3-Methoxymandelic Acid
- VMA