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Homocystine Quantitative, Urine
0080413
Ordering Recommendation

Monitor patients with homocystinuria.

Mnemonic
HOMOCYS-U
Methodology
Spectrophotometry
Performed
Tue
Reported
2-10 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Patients should abstain from vitamin C ingestion for 48 hours prior to specimen collection. 
Collect
24-hour urine. Specimen must be refrigerated during collection. Also acceptable: Random urine (reported as homocystine/creatinine ratios). 
Specimen Preparation
Mix well. Transfer 5 mL urine to ARUP Standard Transport Tubes. (Min: 3 mL) Record total volume and collection time interval on transport tube and test request form. 
Storage/Transport Temperature
Frozen. 
Unacceptable Conditions
pH less than 5 or greater than 8. Specimens with acid or other preservatives. Ascorbic acid interferes with this assay. Large amounts of blood or hemoglobin can interfere with quantitation. 
Remarks
 
Stability
Ambient: Unacceptable; Refrigerated: 24 hours; Frozen: 1 month 
Reference Interval
Test Number
Components
Reference Interval
 Homocystine - per 24h0-32 mg/d
 Homocystine - per CRT0-53 mg/g crt
 Creatinine, Urine - per 24h
AgeMaleFemale
3-8 years140-700 mg/d140-700 mg/d
9-12 years300-1300 mg/d300-1300 mg/d
13-17 years500-2300 mg/d400-1600 mg/d
18-50 years1000-2500 mg/d700-1600 mg/d
51-80 years800-2100 mg/d500-1400 mg/d
81 years and older600-2000 mg/d400-1300 mg/d


Interpretive Data
For timed specimens other than 24 hours, the result will be extrapolated to represent a 24 hour time period. Reference ranges may not apply.

Compliance Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
To diagnose/monitor patients with homocystinuria, the preferred tests are Amino Acids Quantitative by LC-MS/MS, Plasma (ARUP test code 2009389) and Homocysteine, Total (ARUP test code 0099869).
CPT Code(s)
82131
Components
Component Test Code*Component Chart NameLOINC
0020207Creatinine, Urine - per volume2161-8
0020208Creatinine, Urine - per 24h2162-6
0080417Homocystine - per volume2431-5
0080418Homocystine - per 24h6884-1
0080419Homocystine - per CRT13759-6
0097110Total Volume19153-6
0097111Hours Collected30211-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Urine homocystine