Serotonin, Whole Blood
Ordering Recommendation

Use to diagnose and monitor carcinoid tumors. Preferred serotonin test since most of the blood serotonin resides in the platelets.

Quantitative High Performance Liquid Chromatography
Sun, Tue-Fri
1-5 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Abstain from medications for 72 hours prior to collection. 
Lavender (EDTA) or pink (K2EDTA). 
Specimen Preparation
Place on ice. Transfer 3 mL whole blood to an ARUP Serotonin Transport Tube containing ascorbic acid (ARUP supply #16568). Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 1 mL) Mix well. Specimen must be preserved and frozen within 2 hours of collection. 
Storage/Transport Temperature
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered. 
Unacceptable Conditions
Non-frozen specimens. Specimens other than whole blood. 
Serotonin, Serum (ARUP test code 0080397) is recommended for patients that are difficult to draw. 
After transfer to Serotonin Transport Tube: Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 1 month 
Reference Interval
50-200 ng/mL
Interpretive Data

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Medications that may affect serotonin concentrations include lithium, MAO inhibitors, methyldopa, morphine, and reserpine.  In general, foods that contain serotonin do not interfere significantly.  Slight increases may be seen in acute intestinal obstruction, acute MI, cystic fibrosis, dumping syndromes, and nontropical sprue.  Metastasizing abdominal carcinoid tumors often show serotonin concentrations greater than 400 ng/mL.
Hotline History
Component Test Code*Component Chart NameLOINC
0080395Serotonin, Whole Blood2939-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
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