Catecholamines Fractionated, Plasma
0080216
 
Ordering Recommendation
Not a first-line test for suspected catecholamine-secreting neuroendocrine tumors (pheochromocytoma or neuroblastoma).
Mnemonic
CATE PF
Methodology
Quantitative High Performance Liquid Chromatography
Performed
Sun, Tue-Sat
Reported
1-4 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Patient should be calm and supine for 30 minutes prior to collection.  
Collect
Green (sodium or lithium heparin). Collect on ice.  
Specimen Preparation
Specimen should be centrifuged and frozen within one hour (refrigerated centrifuge is preferred but not required). Transfer 4 mL plasma to an ARUP Standard Transport
Tube. (Min: 2.1 mL)  
Storage/Transport Temperature
Frozen.  
Unacceptable Conditions
EDTA plasma, serum, or urine.  
Remarks
 
Stability
After separation from cells: Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen at -20°C: 1 month; Frozen at -70°C: 1 year  
Reference Interval
Supine
Test Number Components Reference Interval
Epinephrine
Age
2-​10 days
11 days-​3 months
4-​11 months
12-​23 months
24-​35 months
3-​17 years
18 years and older
36-​400 pg/mL
55-​200 pg/mL
55-​440 pg/mL
36-​640 pg/mL
18-​440 pg/mL
18-​460 pg/mL
10-​200 pg/mL
Norepinephrine
Age
2-​10 days
11 days-​3 months
4-​11 months
12-​23 months
24-​35 months
3-​17 years
18 years and older
170-​1180 pg/mL
370-​2080 pg/mL
270-​1120 pg/mL
68-​1810 pg/mL
170-​1470 pg/mL
85-​1250 pg/mL
80-​520 pg/mL
Dopamine2 days and older: 0-​20 pg/mL
Interpretive Data
Small increases in catecholamines (less than 2 times the upper reference limit) usually are the result of physiological stimuli, drugs, or improper specimen collection. Significant elevation of one or more catecholamines (2 or more times the upper reference limit) is associated with an increased probability of a neuroendocrine tumor. Measurement of plasma or urine fractionated metanephrines provides better diagnostic sensitivity than measurement of catecholamines.
Note
Medications that may interfere with catecholamines and metabolites include amphetamines and amphetamine-like compounds, appetite suppressants, bromocriptine, buspirone, caffeine, carbidopa-levodopa (Sinemet), clonidine, dexamethasone, diuretics (in doses sufficient to deplete sodium), ethanol, isoproterenol, labetalol, methyldopa (Aldomet), MAO inhibitors, nicotine, nose drops, propafenone (Rythmol), reserpine, theophylline, tricyclic antidepressants, and vasodilators. The effect of drugs on catecholamine results may not be predictable.

For optimum results, patient should be supine for 30 minutes prior to collection."Upright" ranges typically show epinephrine up to 900 pg/mL, and norepinephrine up to 700 pg/mL, and dopamine essentially unchanged.

Children, particularly those under 2 years of age, often show an elevated catecholamine response to stress.
CPT Code(s)
82384
Components
Component Test Code*Component Chart Name
0080069Catecholamine Interpretation
0080211Dopamine
0080212Epinephrine
0080213Norepinephrine
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, contact interface support at interface.support@aruplab.com.
Cross References
  • Adrenalin
  • Catecholamine Fractionation
  • Catecholamines, Free
  • Dopamine
  • Epinephrine
  • Noradrenaline
  • Norepinephrine
  • Plasma Catecholamines