Proinsulin, Intact/Insulin Ratio
0070256
Ordering Recommendation
Aids in the detection of insulinoma. Do not use to diagnose diabetes mellitus.
Mnemonic
PRO INS
Methodology
Quantitative Chemiluminescent Immunoassay/Quantitative Chemiluminescent Immunoassay
Performed
Refer to individual components
Reported
1-6 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
Patient must be fasting for 12-15 hours prior to collection.  
Collect
Serum separator tube. Also acceptable: Lavender (EDTA) or pink (K2EDTA).  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube and freeze immediately. (Min: 0.8 mL)  
Storage/Transport Temperature
Frozen.  
Unacceptable Conditions
Heparinized plasma. Vitreous or I.V. fluids. Hemolyzed specimens.  
Remarks
  
Stability
After separation from cells: Ambient: Unacceptable; Refrigerated: 48 hours; Frozen: 2 months (avoid repeated freeze/thaw cycles)  
Reference Interval
 
 
Available Separately Component Reference Interval
Yes (0070063) Insulin, Fasting 3-​19 µIU/mL
Yes (0070112) Proinsulin, Intact 0-​17 years: Not established
Effective May 19th, 2014
18 years and older: Less than or equal to 8.0 pmol/L
No Proinsulin, Intact/Insulin Ratio Calculation Proinsulin, Intact/Insulin Ratio as Percent:
0-​17 years: Not established
18 years and older: 0.8-​21.7 percent
Interpretive Data
Insulin, Fasting: This test reacts on a nearly equimolar basis with the analogs insulin aspart, insulin glargine, and insulin lispro. Insulin detemir exhibits approximately 50 percent cross-reactivity. Test reactivity with insulin glulisine is negligible (less than 3 percent). To convert to pmol/L, multiply µIU/mL by 6.0.

Proinsulin, Intact: Fasting intact proinsulin values above the reference interval indicate a possible insulin secreting pancreatic tumor (insulinoma) in patients with hypoglycemia. Fasting intact proinsulin values range from 3 to 50 pmol/L in patients with untreated type 2 diabetes.

See Compliance Statement D: www.aruplab.com/CS  
Note
 
CPT Code(s)
84206; 83525
Components
Component Test Code*Component Chart Name
0070063Insulin, Fasting
0070112Proinsulin, Intact
0070257Proinsulin, Intact/Insulin Ratio Calc
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases