Prostatic Acid Phosphatase
0070120
Ordering Recommendation
Obsolete test for prostate cancer screening; preferred test is total prostate specific antigen (0070121) in conjunction with digital rectal exam.
Mnemonic
PAP
Methodology
Quantitative Chemiluminescent Immunoassay
Performed
Sun-Sat
Reported
Within 24 hours  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
Specimen should be obtained before rectal examination, biopsy, prostatectomy or prostatic massage, since manipulation of the prostate gland may lead to elevated PAP levels persisting up to 24-48 hours.  
Collect
Serum separator tube.  
Specimen Preparation
Allow specimen to clot completely at room temperature. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)  
Storage/Transport Temperature
Frozen. Separate specimens must be submitted when multiple tests are ordered.  
Unacceptable Conditions
Specimens refrigerated more than 24 hours or left at room temperature more than 3 hours.  
Remarks
 
Stability
After separation from cells: Ambient: 3 hours; Refrigerated: 24 hours; Frozen: 6 months  
Reference Interval
0.0-3.5 ng/mL  
Interpretive Data
The Siemens Immulite2000 PAP chemiluminescent immunoassay method is used. Results obtained with different assay methods or kits cannot be used interchangeably. PAP may be of some use in predicting disease recurrence or monitoring treatment effects. It has little clinical utility as a screening test for prostate cancer. Prostate specific antigen (PSA) is the preferred test for prostate cancer screening, monitoring, and predicting outcomes. Benign prostatic hyperplasia, prostate massage, and prostatic infarction may result in elevated PAP concentrations. The PAP assay value, regardless of level, should not be interpreted as absolute evidence for the presence or absence of malignant disease.  
Note
 
CPT Code(s)
84066
Components
Component Test Code*Component Chart Name
0070120Prostatic Acid Phosphatase
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Aliases
  • Acid Phosphatase
  • Acid Phosphatase, Prostatic Isoenzyme,
  • PAP