Proinsulin, Intact
0070112
Ordering Recommendation
Aids in the detection of insulinoma. Do not use to diagnose diabetes mellitus.
Mnemonic
PROINS
Methodology
Quantitative Chemiluminescent Immunoassay
Performed
Tue, Thu
Reported
1-6 days  
New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Submit With Order
Specimen Required
Patient Preparation
Patient must fast for 12-15 hours prior to collection.  
Collect
Serum separator tube or plain red. Also acceptable: Lavender (EDTA) or pink (K2EDTA).  
Specimen Preparation
Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube and freeze immediately. (Min: 0.2 mL)  
Storage/Transport Temperature
Frozen.  
Unacceptable Conditions
Grossly hemolyzed specimens.  
Remarks
  
Stability
After separation from cells: Ambient: Unacceptable; Refrigerated: 48 hours; Frozen: 2 months (avoid repeated freeze/thaw cycles)  
Reference Interval
Effective May 19, 2014
 
Age Reference Interval
0-​17 years Not established
18 years and older Less than or equal to 8.0 pmol/L
Interpretive Data
Fasting intact proinsulin values above the reference interval indicate a possible insulin secreting pancreatic tumor (insulinoma) in patients with hypoglycemia. Fasting intact proinsulin values range from 3 to 50 pmol/L in patients with untreated type 2 diabetes.

See Compliance Statement D: www.aruplab.com/CS  
Note
 
CPT Code(s)
84206
Components
Component Test Code*Component Chart Name
0070112Proinsulin, Intact
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Proinsulin, Plasma