Aldosterone/Renin Activity Ratio
Ordering Recommendation

Screen and diagnose hyperaldosteronism.

Quantitative Chemiluminescent Immunoassay/Quantitative Enzyme-Linked Immunosorbent Assay
1-5 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Collect midmorning after patient has been sitting, standing, or walking for at least 2 hours, and seated for 5-15 minutes. Refer to the Additional Technical Information for specific patient preparation recommendations. 
Serum Separator Tube (SST) AND Lavender (EDTA) or Pink (K2EDTA). Do not collect in refrigerated tubes. 
Specimen Preparation
Separate from cells ASAP or within 2 hours of collection.
Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)
Transfer 2 mL EDTA plasma to an ARUP Standard Transport Tube and freeze immediately. (Min: 1.2 mL) 
Storage/Transport Temperature
Both specimens should be submitted together for testing.
Frozen. Also acceptable: Refrigerated.
Plasma: CRITICAL FROZEN.  Separate specimens must be submitted when additional tests are ordered.
Unacceptable Conditions
Plasma collected in citrate, heparin, or oxalate. Hemolyzed specimens. 
Serum: Ambient: 8 hours; Refrigerated: 5 days; Frozen: 1 month
Plasma: Ambient: 6 hours; Refrigerated: Unacceptable; Frozen: 1 month 
Reference Interval
Test Number
Reference Interval
0070015Aldosterone, SerumEffective May 16, 2011
Posture Unspecified
0-6 days5.0-102.0 ng/dL
1-3 weeks6.0-179.0 ng/dL
1-11 months7.0-99.0 ng/dL
1-2 years7.0-93.0 ng/dL
3-10 years4.0-44.0 ng/dL
11-14 years4.0-31.0 ng/dL
15 years and olderLess than or equal to 31.0 ng/dLLess than or equal to 16.0 ng/dL4.0-31.0 ng/dL

0070105Renin Activity
Adult, normal sodium diet
Children, normal sodium diet, supine:
Children, normal sodium diet, upright:
Supine: 0.2-1.6 ng/mL/hrNewborn (1-7 days): 2.0-35.0 ng/mL/hr0-3 years: Not Available
Upright: 0.5-4.0 ng/mL/hrCord blood: 4.0-32.0 ng/mL/hr4-5 years: Less than or equal to 15 ng/mL/hr
1-12 months: 2.4-37.0 ng/mL/hr6-10 years: Less than or equal to 17 ng/mL/hr
13 months-3 years:1.7-11.2 ng/mL/hr11-15 years: Less than or equal to 16 ng/mL/hr
4-5 years:1.0-6.5 ng/mL/hr
6-10 years: 0.5-5.9 ng/mL/hr
11-15 years: 0.5-3.3 ng/mL/hr

 Aldosterone/Renin Activity CalculationEffective May 16, 2011

Less than or equal to 25
An Aldosterone/Renin Activity Ratio of greater than 25 is suggestive of hyperaldosteronism if the aldosterone concentration is greater than 15 ng/dL.

Interpretive Data

Compliance Statement D: For laboratory tests using a manufactured RUO kit. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Refer to the Additional Technical Information for Endocrine Society recommendations for patient preparation, specimen collection, medications for hypertension control during confirmatory testing for primary aldosteronism, and factors that may lead to false-positive or false-negative ARR results.
Hotline History
Component Test Code*Component Chart NameLOINC
0070074Aldosterone/Renin Activity Calculation30894-0
0070105Renin Activity2915-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Aldosterone and Plasma Renin Activity
  • Aldosterone serum
  • Aldosterone/Renin Activity
  • ARR
  • ARR-P
  • PRA
  • Renin Activity