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Aldosterone/Renin Activity Ratio
0070073
Ordering Recommendation

Diagnose and screen for primary hyperaldosteronism.

Mnemonic
A/RA
Methodology
Quantitative Chemiluminescent Immunoassay
Performed
Sun-Sat
Reported
1-5 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Supine:  1. Both specimens should be obtained between 8 a.m. and 10 a.m. (after at least two hours in supine position); 2. Normal sodium diet (100-200 mEq/day) for at least three days; 3. Receiving no medications known to affect renin-aldosterone system.
Upright:
1. Both specimens should be obtained before noon (after at least two hours in upright position, seated or standing); 2. Normal sodium diet (100-200 mEq/day) for at least three days; 3. Receiving no medications known to affect renin-aldosterone system.
Contact Medical Director if more information is needed.  
Collect
From either a supine or upright patient, serum separator tube AND lavender (EDTA) or pink (K2EDTA). Do not collect in refrigerated tubes.  
Specimen Preparation
Separate from cells ASAP. Transfer 1 mL serum AND 2 mL EDTA plasma to individual ARUP Standard Transport Tubes and freeze immediately. (Min: 0.5 mL serum AND 1.2 mL EDTA plasma)  
Storage/Transport Temperature
CRITICAL FROZEN.  Separate specimens must be submitted when additional tests are ordered.  
Unacceptable Conditions
Refrigerated plasma. Hemolyzed specimens.  
Remarks
 
Stability
After separation from cells: Ambient: 8 hours; Refrigerated: Unacceptable; Frozen: 1 month  
Reference Interval
Test Number
Components
Reference Interval
0070015Aldosterone, SerumEffective May 16, 2011
Age
Posture Unspecified
Supine
Upright
0-6 days5.0-102.0 ng/dL
1-3 weeks6.0-179.0 ng/dL
1-11 months7.0-99.0 ng/dL
1-2 years7.0-93.0 ng/dL
3-10 years4.0-44.0 ng/dL
11-14 years4.0-31.0 ng/dL
15 years and olderLess than or equal to 31.0 ng/dLLess than or equal to 16.0 ng/dL4.0-31.0 ng/dL

0070105Renin Activity
Adult, normal sodium diet
Children, normal sodium diet, supine:
Children, normal sodium diet, upright:
Supine: 0.2-1.6 ng/mL/hrNewborn (1-7 days): 2.0-35.0 ng/mL/hr0-3 years: Not Available
Upright: 0.5-4.0 ng/mL/hrCord blood: 4.0-32.0 ng/mL/hr4-5 years: Less than or equal to 15 ng/mL/hr
1-12 months: 2.4-37.0 ng/mL/hr6-10 years: Less than or equal to 17 ng/mL/hr
13 months-3 years:1.7-11.2 ng/mL/hr11-15 years: Less than or equal to 16 ng/mL/hr
4-5 years:1.0-6.5 ng/mL/hr
6-10 years: 0.5-5.9 ng/mL/hr
11-15 years: 0.5-3.3 ng/mL/hr

 Aldosterone/Renin Activity CalculationEffective May 16, 2011

Less than 25
An Aldosterone/Renin Activity Ratio of greater than 25 is suggestive of hyperaldosteronism if the aldosterone concentration is greater than 15 ng/dL.


Interpretive Data


Note
CPT Code(s)
82088; 84244
Components
Component Test Code*Component Chart NameLOINC
0070015Aldosterone1763-2
0070074Aldosterone/Renin Activity Calculation30894-0
0070105Renin Activity2915-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Aldosterone and Plasma Renin Activity
  • Aldosterone serum
  • Aldosterone/Renin Activity
  • ARR
  • ARR-P
  • PRA
  • Renin Activity