Aldosterone/Renin Activity Ratio
0070073
 
Ordering Recommendation
Mnemonic
A/RA
Methodology
Quantitative Radioimmunoassay
Performed
Sun-Sat
Reported
1-5 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Supine: 1. Both specimens should be obtained between 8 a.m. and 10 a.m. (after at least two hours in supine position); 2. Normal sodium diet (100-200 mEq/day) for at least three days; 3. Receiving no medications known to affect renin-aldosterone system.
Upright:
1. Both specimens should be obtained before noon (after at least two hours in upright position, seated or standing); 2. Normal sodium diet (100-200 mEq/day) for at least three days; 3. Receiving no medications known to affect renin-aldosterone system.
Contact Medical Director if more information is needed.  
Collect
From either a supine or upright patient, serum separator tube or green (sodium or lithium heparin) AND lavender (EDTA) or pink (K2EDTA). Do not collect in refrigerated tubes.  
Specimen Preparation
Separate from cells ASAP. Transfer 1 mL serum or heparinized plasma AND 2 mL EDTA plasma to individual ARUP Standard Transport Tubes and freeze immediately. (Min: 0.5 mL serum or heparinized plasma AND 1.2 mL EDTA plasma)  
Storage/Transport Temperature
CRITICAL FROZEN. Separate specimens must be submitted when additional tests are ordered.  
Unacceptable Conditions
Refrigerated plasma. Hemolyzed specimens.  
Remarks
 
Stability
After separation from cells: Ambient: 4 hours; Refrigerated: Unacceptable; Frozen: 1 month  
Reference Interval
Test Number Components Reference Interval
0070015Aldosterone, Serum Effective May 16, 2011
Age Posture Unspecified Supine Upright
0-​6 days 5.0-​102.0 ng/dL
1-​3 weeks 6.0-​179.0 ng/dL
1-​11 months 7.0-​99.0 ng/dL
1-​2 years 7.0-​93.0 ng/dL
3-​10 years 4.0-​44.0 ng/dL
11-​14 years 4.0-​31.0 ng/dL
15 years and older Less than or equal to 31.0 ng/dL Less than or equal to 16.0 ng/dL 4.0-​31.0 ng/dL
0070105Renin Activity
Adult, normal sodium diet Children, normal sodium diet, supine: Children, normal sodium diet, upright:
Supine: 0.2-​1.6 ng/mL/hr Newborn (1-​7 days): 2.0-​35.0 ng/mL/hr 0-​3 years: Not Available
Upright: 0.5-​4.0 ng/mL/hr Cord blood: 4.0-​32.0 ng/mL/hr 4-​5 years: Less than or equal to 15 ng/mL/hr
1-​12 months: 2.4-​37.0 ng/mL/hr 6-​10 years: Less than or equal to 17 ng/mL/hr
13 months-​3 years:1.7-​11.2 ng/mL/hr 11-​15 years: Less than or equal to 16 ng/mL/hr
4-​5 years:1.0-​6.5 ng/mL/hr
6-​10 years: 0.5-​5.9 ng/mL/hr
11-​15 years: 0.5-​3.3 ng/mL/hr
Aldosterone/Renin Activity Calculation Effective May 16, 2011

Less than 25
An Aldosterone/Renin Activity Ratio of greater than 25 is suggestive of hyperaldosteronism if the aldosterone concentration is greater than 15 ng/dL.
Interpretive Data
Note
CPT Code(s)
82088; 84244
Components
Component Test Code*Component Chart Name
0070015Aldosterone
0070074Aldosterone/Renin Activity Calculation
0070105Renin Activity
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, contact interface support at interface.support@aruplab.com.
Cross References
  • Aldosterone and Plasma Renin Activity
  • Aldosterone serum
  • Aldosterone/Renin Activity
  • ARR
  • ARR-P
  • PRA
  • Renin Activity