Aldosterone/Renin Activity Ratio
0070073
Ordering Recommendation
 
Mnemonic
A/RA
Methodology
Quantitative Chemiluminescent Immunoassay
Performed
Sun-Sat
Reported
1-5 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
Supine:  1. Both specimens should be obtained between 8 a.m. and 10 a.m. (after at least two hours in supine position); 2. Normal sodium diet (100-200 mEq/day) for at least three days; 3. Receiving no medications known to affect renin-aldosterone system.
Upright:
1. Both specimens should be obtained before noon (after at least two hours in upright position, seated or standing); 2. Normal sodium diet (100-200 mEq/day) for at least three days; 3. Receiving no medications known to affect renin-aldosterone system.
Contact Medical Director if more information is needed.  
Collect
From either a supine or upright patient, serum separator tube AND lavender (EDTA) or pink (K2EDTA). Do not collect in refrigerated tubes.  
Specimen Preparation
Separate from cells ASAP. Transfer 1 mL serum AND 2 mL EDTA plasma to individual ARUP Standard Transport Tubes and freeze immediately. (Min: 0.5 mL serum AND 1.2 mL EDTA plasma)  
Storage/Transport Temperature
CRITICAL FROZEN.  Separate specimens must be submitted when additional tests are ordered.  
Unacceptable Conditions
Refrigerated plasma. Hemolyzed specimens.  
Remarks
  
Stability
After separation from cells: Ambient: 8 hours; Refrigerated: Unacceptable; Frozen: 1 month  
Reference Interval
 
 
Test Number Components Reference Interval
0070015Aldosterone, Serum Effective May 16, 2011
 
Age Posture Unspecified Supine Upright
0-​6 days 5.0-​102.0 ng/dL   
1-​3 weeks 6.0-​179.0 ng/dL   
1-​11 months 7.0-​99.0 ng/dL   
1-​2 years 7.0-​93.0 ng/dL   
3-​10 years 4.0-​44.0 ng/dL   
11-​14 years 4.0-​31.0 ng/dL   
15 years and older Less than or equal to 31.0 ng/dL Less than or equal to 16.0 ng/dL 4.0-​31.0 ng/dL
0070105Renin Activity  
 
Adult, normal sodium diet Children, normal sodium diet, supine:  Children, normal sodium diet, upright: 
Supine: 0.2-​1.6 ng/mL/hr Newborn (1-​7 days): 2.0-​35.0 ng/mL/hr 0-​3 years: Not Available
Upright: 0.5-​4.0 ng/mL/hr Cord blood: 4.0-​32.0 ng/mL/hr 4-​5 years: Less than or equal to 15 ng/mL/hr
 1-​12 months: 2.4-​37.0 ng/mL/hr 6-​10 years: Less than or equal to 17 ng/mL/hr
 13 months-​3 years:1.7-​11.2 ng/mL/hr 11-​15 years: Less than or equal to 16 ng/mL/hr
 4-​5 years:1.0-​6.5 ng/mL/hr  
 6-​10 years: 0.5-​5.9 ng/mL/hr  
 11-​15 years: 0.5-​3.3 ng/mL/hr  
 Aldosterone/Renin Activity Calculation Effective May 16, 2011

Less than 25
An Aldosterone/Renin Activity Ratio of greater than 25 is suggestive of hyperaldosteronism if the aldosterone concentration is greater than 15 ng/dL.
 
Interpretive Data
 
Note
 
CPT Code(s)
82088; 84244
Components
Component Test Code*Component Chart NameLOINC
0070015Aldosterone1763-2
0070074Aldosterone/Renin Activity Calculation30894-0
0070105Renin Activity2915-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Aldosterone and Plasma Renin Activity
  • Aldosterone serum
  • Aldosterone/Renin Activity
  • ARR
  • ARR-P
  • PRA
  • Renin Activity