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N-Telopeptide, Cross-Linked, Urine
0070062
Ordering Recommendation
Mnemonic
NTX
Methodology
Quantitative Chemiluminescent Immunoassay
Performed
Tue-Sat
Reported
1-4 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
For monitoring therapy, a baseline specimen should be collected prior to initiation of therapy. Subsequent specimens for comparison should be collected at the same time of day as the baseline specimen. 
Collect
Second-morning void or 24-hour urine. Refrigerate during collection. Collect without preservative. 
Specimen Preparation
Transfer a 1 mL aliquot of urine from a well-mixed, second-morning void or 24-hour collection to an ARUP Standard Transport Tube. (Min: 0.5 mL) 
Storage/Transport Temperature
Frozen. 
Unacceptable Conditions
Specimens contaminated with blood or extensive hemolysis. 
Remarks
 
Stability
Ambient: 24 hours; Refrigerated: 1 week; Frozen: 2 years 
Reference Interval
Age
Male
Female
7-9 years167-578 nM BCE/mM creatinine201-626 nM BCE/mM creatinine
10-12 years152-505 nM BCE/mM creatinine173-728 nM BCE/mM creatinine
13-15 years103-776 nM BCE/mM creatinine38-515 nM BCE/mM creatinine
16-17 years34-313 nM BCE/mM creatinine20-144 nM BCE/mM creatinine
18 years and older21-83 nM BCE/mM creatinine
Premenopausal 17-94 nM BCE/mM creatinine
Postmenopausal 26-124 nM BCE/mM creatinine

Interpretive Data
NTx Units=nM BCE/mM creatinine

A decrease of 30-40% from the NTx baseline after three months of therapy is a typical response to anti-resorptive therapy.

NTx=Cross-linked N-telopeptide of Type I Collagen
BCE=Bone Collagen Equivalent

Note
CPT Code(s)
82523
Components
Component Test Code*Component Chart NameLOINC
0020207Creatinine, Urine - per volume2161-8
0070061NTx, Urine (nM BCE/mM Creatinine)14115-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Collagen Crosslinks
  • Cross-Linked N-Telopeptide
  • Crosslinked N-telopeptide of Type I Collagen
  • N-Telopeptide, Urine
  • NTx
  • NTX Creatinine
  • NTX Urine
  • Osteomark
  • Osteoporosis