Histamine, Urine
Ordering Recommendation
Aid in evaluation of patient with allergic signs and symptoms, such as anaphylaxis; may assist in diagnosing and monitoring of mast-cell activation.
Quantitative Enzyme Immunoassay
Tue, Sat
1-6 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
Random or 24-hour urine in a plastic container. Refrigerate during collection.  
Specimen Preparation
Transfer a 4 mL aliquot from a well-mixed random or 24-hour collection to an ARUP Standard Transport Tube and freeze immediately. (Min: 1 mL) Record total volume and collection time interval on transport tube and test request form.  
Storage/Transport Temperature
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.  
Unacceptable Conditions
Room temperature specimens.  
Ambient: Unacceptable; Refrigerated: 24 hours; Frozen: 6 months  
Reference Interval
Effective February 21, 2012
Components Reference Interval
Histamine, Urine -​ ratio to CRT 0-​450 nmol/g crt
Histamine, Urine, Excretion -​ 24h 0-​60 µg/day
Interpretive Data

Compliance Statement D: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
If 24-hour urine is submitted, the excretion will be calculated. If random urine is submitted, the result will be reported as Not applicable.
CPT Code(s)
Component Test Code*Component Chart NameLOINC
0020207Creatinine, Urine - per volume2161-8
0070039Histamine, Urine - per volume33290-8
0070041Histamine, Urine - ratio to CRT25925-9
0097110Total Volume19153-6
0097111Hours Collected30211-7
2005776Histamine, Urine, Excretion - 24 h9410-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
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