Human Papillomavirus (HPV), High Risk by Hybrid Capture, Cervical Brush (INACTIVE as of 08/21/17)
Ordering Recommendation

FDA-approved test for routine cervical cancer screening in combination with cervical cytology (Pap smear) in women 30 years. Follow-up test for abnormal cytology results in women ≥21 years.

Qualitative Nucleic Acid Probe
3-10 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Females should avoid high concentrations of antifungal cream, contraceptive jelly, or douche at time of collection. 
Cervical brush in HPV Digene Collection Kit (ARUP supply #12578). Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. 
Specimen Preparation
Place each specimen in an individually sealed bag. (Min: 1 mL) 
Storage/Transport Temperature
Room temperature. Also acceptable: Refrigerated. 
Unacceptable Conditions
Specimens in any transport media other than indicated above.
For specimens in ThinPrep Pap Test transport media, refer to Human Papillomavirus (HPV), High Risk, E6/E7 mRNA by Transcription-Mediated Amplification (TMA) (ARUP test code 2007893) or Human Papillomavirus (HPV), High Risk by Hybrid Capture, ThinPrep (ARUP test code 2008404); for specimens in SurePath Pap specimen transport media, refer to Human Papillomavirus (HPV), High Risk by PCR, SurePath (ARUP test code 2011942). 
Specimen source required. 
Ambient: 2 weeks; Refrigerated: 3 weeks; Frozen: 3 months 
Reference Interval
Interpretive Data
This test detects the high-risk HPV genotypes 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and 68 associated with cervical cancer and its precursor lesions. However, cross-reactions with other genotypes may occur. Results should be correlated with cytologic and histologic findings. Sensitivity may be affected by cellularity of specimen.

This test is intended for medical purposes only and is not valid for the evaluation of suspected sexual abuse or for other forensic purposes.

HPV testing should not be used for screening or management of atypical squamous cells of undetermined significance (ASCUS) in women under age 21.

A negative result does not rule out the presence of an HPV genotype absent from the test panel, a low level infection, or specimen sampling error. 
Component Test Code*Component Chart NameLOINC
0060752HPV Source31208-2
0065143HPV High Risk, Hybrid Capture, Brush30167-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • HPV High-Risk
  • HPV HR cervical brush
  • HPV HR hybrid capture
  • Hybrid Capture