Thrombotic Risk, DNA Panel
0056200
Ordering Recommendation
Acceptable panel to detect the two most common inherited thrombophilias (prothrombin-related and factor V Leiden-related).
Submit With Order
Mnemonic
THROMDNA
Methodology
Polymerase Chain Reaction
Performed
Sun-Sat
Reported
2-7 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
 
Collect
Lavender (EDTA) or pink (K2 EDTA). Also acceptable: Yellow (ACD Solution A), lt. blue (sodium citrate), or green (sodium or lithium heparin).  
Specimen Preparation
Do not freeze. Transport 5 mL whole blood. (Min: 3 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Serum. Frozen specimens. Clotted or severely hemolyzed specimens.  
Remarks
 
Stability
Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable  
Reference Interval
Test Number Components Reference Interval
0097720Factor V Leiden (F5) R506Q Mutation Negative: This sample is negative for factor V Leiden, R506Q mutation.
0055655Methylenetetrahydrofolate Reductase (MTHFR) 2 Mutations Effective February 18, 2014
Negative:
Neither of the common MTHFR gene mutations tested, c.665C>T and c.1286A>C, were detected. Other causes of elevated homocysteine levels, coronary heart disease, or thrombosis were not assessed. This genotype is associated with a normal folate metabolism.
0056060Prothrombin (F2) G20210A Mutation Negative: This sample is negative for the factor II, prothrombin 20210A mutation.
Interpretive Data
Note
CPT Code(s)
81240, 81241, 81291
Components
Cross References
  • FVL R506Q, MTHFR, and Factor II mutation panel
  • Hypercoag
  • Hypercoagulable Panel