Vitamin B12 with Reflex to Methylmalonic Acid, Serum (Vitamin B12 Status)
0055662
Ordering Recommendation
Preferred reflex test for detection of vitamin B12 deficiency in individuals with macrocytic or unexplained anemia, or unexplained neurologic disease.
Mnemonic
B12 MMA
Methodology
Quantitative Chemiluminescent Immunoassay/Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry
Performed
Sun-Sat
Reported
1-3 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Plain red or serum separator tube. Also acceptable: Green (sodium or lithium heparin).  
Specimen Preparation
Protect from light during collection, storage and shipment. Centrifuge and remove serum from cells within 2 hours of collection. Transfer 2 mL serum or plasma to an ARUP Standard Transport Tube and refrigerate or freeze immediately. (Min: 1.5 mL)  
Storage/Transport Temperature
Frozen.  
Unacceptable Conditions
EDTA plasma. Room temperature specimens. Grossly hemolyzed or lipemic specimens.  
Remarks
  
Stability
After separation from cells: Ambient: Unacceptable; Refrigerated: 48 hours; Frozen: 1 month  
Reference Interval
 
 
Available Separately Components Reference Interval
Yes (0070150) Vitamin B12 Effective December 2, 2013
180-​914 pg/mL
No Methylmalonic Acid, Serum (Vitamin B12 Deficiency) 0.00-​0.40 µmol/L
Interpretive Data
 
Note
If Vitamin B12 is less than 300 pg/mL, then Methylmalonic Acid, Serum (Vitamin B12 Status) will be added. Additional charges apply.
CPT Code(s)
82607; if reflexed, add 83921
Components
Component Test Code*Component Chart NameLOINC
0055663Vitamin B12 Status 
0055664Methylmalonic Acid, Serum 
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • B12 (Cobalamin)
  • B12 and MMA reflex
  • B12 Assay
  • B12 MMA
  • B12, Serum
  • CblC
  • Cobalamin
  • Methylcobalamin
  • Vit B12 and MMA