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Vitamin B[12] with Reflex to Methylmalonic Acid, Serum (Vitamin B[12] Status)
0055662
Ordering Recommendation
Preferred reflex test for detection of vitamin B12 deficiency in individuals with macrocytic or unexplained anemia, or unexplained neurologic disease.
Mnemonic
B12 MMA
Methodology
Quantitative Chemiluminescent Immunoassay/Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry
Performed
Sun-Sat
Reported
1-3 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Plain red or serum separator tube. Also acceptable: Green (sodium or lithium heparin).  
Specimen Preparation
Protect from light during collection, storage and shipment. Centrifuge and remove serum from cells within 2 hours of collection. Transfer 2 mL serum or plasma to an ARUP Standard Transport Tube and refrigerate or freeze immediately. (Min: 1.5 mL)  
Storage/Transport Temperature
Frozen.  
Unacceptable Conditions
EDTA plasma. Room temperature specimens. Grossly hemolyzed or lipemic specimens.  
Remarks
 
Stability
After separation from cells: Ambient: Unacceptable; Refrigerated: 48 hours; Frozen: 1 month  
Reference Interval
Available Separately
Components
Reference Interval
Yes (0070150)Vitamin B12Effective December 2, 2013
180-914 pg/mL
NoMethylmalonic Acid, Serum (Vitamin B12 Deficiency)0.00-0.40 µmol/L

Interpretive Data


Note
If Vitamin B12 is less than 300 pg/mL, then Methylmalonic Acid, Serum (Vitamin B12 Status) will be added. Additional charges apply.
CPT Code(s)
82607; if reflexed, add 83921
Components
Component Test Code*Component Chart NameLOINC
0055663Vitamin B12 Status
0055664Methylmalonic Acid, Serum
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • B12 (Cobalamin)
  • B12 and MMA reflex
  • B12 Assay
  • B12 MMA
  • B12, Serum
  • CblC
  • Cobalamin
  • Methylcobalamin
  • Vit  B12 and MMA