Cyclic Citrullinated Peptide (CCP) Antibody, IgG
0055256
Ordering Recommendation
Highly specific serologic test that aids in the workup of suspected rheumatoid arthritis or undifferentiated inflammatory arthritides.  Rheumatoid Arthritis Panel (2003277) is preferred test.
Mnemonic
CCP IGG
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Sun-Sat
Reported
Within 24 hours  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Serum separator tube.  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Urine or plasma. Contaminated, hemolyzed, grossly icteric, heat-inactivated, or severely lipemic specimens.  
Remarks
  
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)  
Reference Interval
19 Units or less: Negative
20-39 Units: Weak positive
40-59 Units: Moderate positive
60 Units or Greater: Strong positive  
Interpretive Data
Anti-cyclic citrullinated peptide (anti-CCP), IgG antibodies are present in about 69-83 percent of patients with rheumatoid arthritis (RA) and have specificities of 93-95 percent. These autoantibodies may be present in the preclinical phase of disease, are associated with future RA development, and may predict radiographic joint destruction. Patients with weak positive results should be monitored and testing repeated.  
Note
 
CPT Code(s)
86200
Components
Component Test Code*Component Chart NameLOINC
0055256Cyclic Citrullinated Peptide Ab, IgG33935-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • ACPA Antibody
  • Anti Citrullinated Antibody
  • Anti Citrulline
  • Anti-CCP
  • Anti-CCP Antibody
  • Anti-Citrullinated Ab
  • Anti-Citrullinated Antibody
  • Anti-Citrullinated Protein/Peptide Antibody (ACPA)
  • Anti-Citrulline Antibody
  • Anti-Cyclic Citrullinated Peptide
  • AntiCCP Antibody
  • Anticitrullinated Antibody
  • Anticitrullinated Protein/Peptide Antibody (ACPA)
  • Anticitrulline Antibody
  • Anticyclic Citrullinated Peptide (CCP) Antibody
  • CCP
  • CCP3 Antibody
  • Citrullinated Ab
  • Citrullinated Antibody
  • Citrullinated Protein/Peptide Antibody (ACPA)
  • Citrulline Antibody
  • Soft-CCP