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Liver-Kidney Microsome - 1 Antibody, IgG
0055241
Ordering Recommendation

Differential evaluation of autoimmune liver disease of unknown etiology, especially autoimmune hepatitis (AIH) of childhood onset. Use in combination with IgG testing for type1 liver cystolic antigen (2010711) when evaluating for AIH-2.

Mnemonic
LKM1 IGG
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Sun, Tue, Thu
Reported
1-4 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Serum separator tube. 
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL) 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
Contaminated, heat-inactivated, hemolyzed, or lipemic specimens. 
Remarks
 
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles) 
Reference Interval
0.0-20.0 U: Negative
20.1-24.9 U: Equivocal
Greater than or equal to 25.0 U: Positive
Interpretive Data
A positive result indicates the presence of IgG antibodies to recombinant human P450 2D6 and suggests the possibility of autoimmune hepatitis, type 2.A negative LKM-1 does not rule out the presence of autoimmune hepatitis, type 2.

Note
CPT Code(s)
86376
Components
Component Test Code*Component Chart NameLOINC
0055241Liver-Kid Microsome-1 Ab, IgG by ELISA47318-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Anti-P450 2D6 Antibody
  • AntiP450 2D6 Antibody, IgG
  • LKM-1 Antibody, IgG
  • LKM-1 IgG
  • LKM1 IgG, LMK1
  • P450 2D6 Antibody, IgG