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Liver-Kidney Microsome - 1 Antibody, IgG
0055241
Ordering Recommendation

Differential evaluation of autoimmune liver disease of unknown etiology, especially autoimmune hepatitis (AIH) of childhood onset. Use in combination with Liver Cytosolic Antigen Type 1 (LC-1) Antibody, IgG (2010711) when evaluating for AIH-2.

Mnemonic
LKM1 IGG
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Sun, Tue, Thu
Reported
1-4 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Serum separator tube. 
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL) 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
Contaminated, heat-inactivated, hemolyzed, or lipemic specimens. 
Remarks
 
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles) 
Reference Interval
0.0-20.0 UNegative
20.1-24.9 UEquivocal
25.0 U or greaterPositive

Interpretive Data
A positive result indicates the presence of IgG antibodies to recombinant human P450 2D6 and suggests the possibility of autoimmune hepatitis, type 2.A negative LKM-1 does not rule out the presence of autoimmune hepatitis, type 2.

Components
Component Test Code*Component Chart NameLOINC
0055241Liver-Kid Microsome-1 Ab, IgG by ELISA47318-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Anti-P450 2D6 Antibody
  • AntiP450 2D6 Antibody, IgG
  • LKM-1 Antibody, IgG
  • LKM-1 IgG
  • LKM1 IgG, LMK1
  • P450 2D6 Antibody, IgG