Cytomegalovirus by Quantitative PCR
Ordering Recommendation

Detect and quantify cytomegalovirus (CMV).

Quantitative Polymerase Chain Reaction
1-3 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Lavender (EDTA) or pink (K2EDTA), or Bronchoalveolar lavage (BAL). 
Specimen Preparation
Separate plasma from cells. Transfer 1 mL plasma, or whole blood, or BAL to a sterile container. (Min: 0.5 mL). 
Storage/Transport Temperature
Whole blood: Refrigerated. All others: Frozen. 
Unacceptable Conditions
Heparinized specimens. 
Specimen source required. 
Plasma: Ambient: 24 hours; Refrigerated: 5 days; Frozen: 1 year 
Whole blood
: Ambient: 7 days; Refrigerated: 7 days; Frozen: 7 days
Ambient: 24 hours; Refrigerated: 5 days; Frozen: 3 months 
Reference Interval
Not detected
Interpretive Data
The quantitative range of this test is 2.6- 6.6 log copies/mL (390-3,900,000 copies/mL) or 2.4- 6.4 log IU/mL (227- 2,270,000 IU/mL). One IU/mL of CMV DNA is approximately 1.72 copies/mL.

A negative result (less than 2.6 log copies/mL [less than 390 copies/mL] OR less than 2.4 log IU/mL [less than 227 IU/mL]) does not rule out the presence of PCR inhibitors in the patient specimen or CMV DNA concentrations below the level of detection of the test. Inhibition may also lead to underestimation of viral quantitation.

Compliance Statement A: For laboratory developed tests using a manufacturer labeled ASR as the reagent providing the specificity of the assay. Analyte Specific Reagent. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, the FDA has determined that such clearance or approval is not necessary.

The limit of quantification for this DNA test is 2.6 log copies/mL (390 copies/mL) or 2.4 log IU/mL (227 IU/mL). If the test DID NOT DETECT the virus, the test result will be reported as "<2.6 log copies/mL (<390 copies/mL)" and "<2.4 log IU/mL (<227 IU/mL)."  If the test DETECTED the presence of the virus but was not able to accurately quantify the number of copies, the test result will be reported as "Not Quantified."
Hotline History
Component Test Code*Component Chart NameLOINC
0051814Cytomegalovirus Quant by PCR, Interp40444-2
0051815Cytomegalovirus Quant by PCR, Log Cpy/mL54206-8
2002316Cytomegalovirus Quant by PCR, Cpy/mL30247-1
2006534Cytomegalovirus Quant by PCR, IU/mL72493-0
2006535Cytomegalovirus Quant by PCR, Log IU/mL72494-8
2012051Cytomegalovirus Quant by PCR, Source31208-2
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