F-Actin (Smooth Muscle) Antibody, IgA
0051724
Ordering Recommendation
Do not use to screen for celiac disease.  May be used to estimate severity of intestinal villous atrophy in confirmed celiac disease.
Mnemonic
ACTIN IGA
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Tue
Reported
1-8 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Serum separator tube.  
Specimen Preparation
Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Plasma. Contaminated, severely hemolyzed, icteric, or lipemic specimens.  
Remarks
  
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year  
Reference Interval
20.0 Units or less: Negative
20.1 - 24.9 Units: Equivocal
25.0 Units or greater: Positive  
Interpretive Data
The presence of IgA antibodies against F-Actin in patients having positive serologic markers for celiac disease, such as antiendomysial, anti-transglutaminase, and/or anti-gliadin peptide IgA, indicates the presence of intestinal villus atrophy. Positive results should be confirmed with biopsy.  
Note
 
CPT Code(s)
83516
Components
Component Test Code*Component Chart Name
0051725F-Actin Antibody, IgA
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • ACTA
  • Actin Antibody
  • Anti-Smooth Muscle Antibody
  • ASMA
  • F-Actin Antibody
  • SMA