Connective Tissue Diseases Profile
0051668
Ordering Recommendation
Confirmatory tests for specific connective tissue disease.
Mnemonic
CONN
Methodology
Semi-Quantitative Multiplex Bead Assay
Performed
Sun-Sat
Reported
1-2 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Serum separator tube.  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Plasma or other body fluids. Bacterially contaminated specimens.  
Remarks
  
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year  
Reference Interval
 
 
Test Number Components Reference Interval
0050085Smith (ENA) Antibody, IgG 29 AU/mL or less: Negative
30-​40 AU/mL: Equivocal
41 AU/mL or greater: Positive
0050470RNP (U1) (Ribonucleic Protein) (ENA) Antibody, IgG 29 AU/mL or less: Negative
30-​40 AU/mL: Equivocal
41 AU/mL or greater: Positive
0050691SSA (Ro) (ENA) Antibody, IgG 29 AU/mL or less: Negative
30-​40 AU/mL: Equivocal
41 AU/mL or greater: Positive
0050692SSB (La) (ENA) Antibody, IgG 29 AU/mL or less: Negative
30-​40 AU/mL: Equivocal
41 AU/mL or greater: Positive
0099592Jo-​1 Antibody, IgG 29 AU/mL or less: Negative
30-​40 AU/mL: Equivocal
41 AU/mL or greater: Positive
0099249Ribosomal P Protein Antibody 29 AU/mL or less: Negative
30-​40 AU/mL: Equivocal
41 AU/mL or greater: Positive
0050714Centromere Antibody, IgG 29 AU/mL or less: Negative
30-​40 AU/mL: Equivocal
41 AU/mL or greater: Positive
0050599Scleroderma (Scl-​70) (ENA) Antibody, IgG 29 AU/mL or less: Negative
30-​40 AU/mL: Equivocal
41 AU/mL or greater: Positive
Interpretive Data
 
Note
 
CPT Code(s)
86235 x6; 83516 x2
Components
Component Test Code*Component Chart NameLOINC
0050085Smith (ENA) Antibody, IgG18323-6
0050470Ribonucleic Protein (U1) (ENA) Ab, IgG38369-5
0050599Scleroderma (Scl-70) (ENA) Antibody, IgG21518-6
0050691SSA (Ro) (ENA) Antibody, IgG31625-7
0050692SSB (La) (ENA) Antibody, IgG29965-1
0050714Centromere Ab, IgG29966-9
0099249Ribosome P Antibody, IgG13636-6
0099592Jo-1 (Histidyl-tRNA Synthetase) Ab, IgG14235-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Anti-ENA Anti-Ribonuclear Protein
  • Anti-RNP
  • Anti-Sm IgG
  • Anti-U1 RNP
  • Antibodies to Extractable Nuclear Antigens
  • Autoantibodies to Scl 70 Antigen
  • Ribonucleoprotein Autoantibodies
  • RNP (Anti-RNP)
  • RNP (U1) (Ribonucleic Protein) (ENA) Antibody, IgG
  • Ro Ab;
  • Scl 70 Antibodies
  • Scleroderma (Scl-70) (ENA) Antibody, IgG
  • Scleroderma Antibodies
  • Smith (ENA) Antibody, IgG
  • Smith Antigen
  • Smith Autoantibodies
  • SmRNP Autoantibodies
  • SSA (Ro) (ENA) Antibody, IgG
    Anti-SSA
  • SSA Ro
  • SSB (La) (ENA) Antibody, IgG
    Anti-SSB
  • SSB LA
  • U1 RNP Ab