Interleukin-1-Receptor-Associated Kinase-4 (IRAK-4) Deficiency Screen
0051393
Ordering Recommendation
 
Mnemonic
IRAK-4
Methodology
Cell Culture/Quantitative Multiplex Bead Assay
Performed
Tue-Fri
Reported
4-9 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Time SensitiveTime Sensitive

Specimen Required
Patient Preparation
Collect control specimen from a healthy individual unrelated to patient.  
Collect
Green (sodium heparin) (patient) AND green (sodium heparin) (control).  Also acceptable: Yellow (ACD solution A). Patient and control specimens must be collected within 48 hours of test performance.  
Specimen Preparation
Transport 4 mL whole blood (patient) AND 4 mL whole blood (control) in original collection tubes. (Min: 2 mL (patient) AND 2 mL (control)) Do not refrigerate or freeze. LIVE LYMPHOCYTES REQUIRED.  
Storage/Transport Temperature
CRITICAL ROOM TEMPERATURE.  
Unacceptable Conditions
Refrigerated or frozen specimens.  
Remarks
 
Stability
Ambient: 48 hours; Refrigerated: Unacceptable; Frozen: Unacceptable  
Reference Interval
By report  
Interpretive Data
Deficiency in cytokine production in response to stimulation suggests possibility of defect in Interleukin-1-Receptor-Associated Kinase-4 (IRAK-4), which may result in recurrent pneumococcal and/or staphylococcal infections, in absence of other abnormalities of host defense.

See Compliance Statement B: www.aruplab.com/CS
Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
 
Note
Interpretation comparing the patient results to the client normal control, as well as the laboratory control, will be provided by the medical director.
CPT Code(s)
86353 x2; 83520 x3
Components
Component Test Code*Component Chart Name
0051393Interleukin-1-Receptor-Assoc Kinase-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • IRAK
  • IRAK screen
  • IRAK4