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Interleukin-1-Receptor-Associated Kinase-4 (IRAK-4) Deficiency Screen (INACTIVE as of 04/04/16)
0051393
Ordering Recommendation
Mnemonic
IRAK-4
Methodology
Cell Culture/Quantitative Multiplex Bead Assay
Performed
Tue-Fri
Reported
4-9 days
New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Submit With Order
Time SensitiveTime Sensitive
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Collect control specimen from a healthy individual unrelated to patient. 
Collect
Green (sodium heparin) (patient) AND green (sodium heparin) (control).  Also acceptable: Yellow (ACD solution A). Patient and control specimens must be collected within 48 hours of test performance. 
Specimen Preparation
Transport 4 mL whole blood (patient) AND 4 mL whole blood (control) in original collection tubes. (Min: 2 mL (patient) AND 2 mL (control)) Do not refrigerate or freeze. LIVE LYMPHOCYTES REQUIRED. 
Storage/Transport Temperature
CRITICAL ROOM TEMPERATURE. 
Unacceptable Conditions
Refrigerated or frozen specimens. 
Remarks
 
Stability
Ambient: 48 hours; Refrigerated: Unacceptable; Frozen: Unacceptable 
Reference Interval
By report
Interpretive Data
Deficiency in cytokine production in response to stimulation suggests possibility of defect in Interleukin-1-Receptor-Associated Kinase-4 (IRAK-4), which may result in recurrent pneumococcal and/or staphylococcal infections, in absence of other abnormalities of host defense.

Compliance Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
Interpretation comparing the patient results to the client normal control, as well as the laboratory control, will be provided by the medical director.
CPT Code(s)
86353 x2; 83520 x3
Components
Component Test Code*Component Chart NameLOINC
0051393Interleukin-1-Receptor-Assoc Kinase-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • IRAK
  • IRAK screen
  • IRAK4