Interleukin-1-Receptor-Associated Kinase-4 (IRAK-4) Deficiency Screen
0051393
Ordering Recommendation
 
Mnemonic
IRAK-4
Methodology
Cell Culture/Quantitative Multiplex Bead Assay
Performed
Tue-Fri
Reported
4-9 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Time SensitiveTime Sensitive

Specimen Required
Patient Preparation
Collect control specimen from a healthy individual unrelated to patient.  
Collect
Green (sodium heparin) (patient) AND green (sodium heparin) (control).  Also acceptable: Yellow (ACD solution A). Patient and control specimens must be collected within 48 hours of test performance.  
Specimen Preparation
Transport 4 mL whole blood (patient) AND 4 mL whole blood (control) in original collection tubes. (Min: 2 mL (patient) AND 2 mL (control)) Do not refrigerate or freeze. LIVE LYMPHOCYTES REQUIRED.  
Storage/Transport Temperature
CRITICAL ROOM TEMPERATURE.  
Unacceptable Conditions
Refrigerated or frozen specimens.  
Remarks
 
Stability
Ambient: 48 hours; Refrigerated: Unacceptable; Frozen: Unacceptable  
Reference Interval
By report  
Interpretive Data
Deficiency in cytokine production in response to stimulation suggests possibility of defect in Interleukin-1-Receptor-Associated Kinase-4 (IRAK-4), which may result in recurrent pneumococcal and/or staphylococcal infections, in absence of other abnormalities of host defense.

See Compliance Statement B: www.aruplab.com/CS  
Note
Interpretation comparing the patient results to the client normal control, as well as the laboratory control, will be provided by the medical director.
CPT Code(s)
86353 x2; 83520 x3
Components
Component Test Code*Component Chart Name
0051393Interleukin-1-Receptor-Assoc Kinase-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • IRAK
  • IRAK screen
  • IRAK4