Epstein-Barr Virus, Quantitative PCR
Ordering Recommendation

Quantify Epstein-Barr virus (EBV) viral load as an aid in monitoring EBV-related disease.

Quantitative Polymerase Chain Reaction
1-4 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Lavender (EDTA), pink (K2EDTA), or serum separator tube. OR CSF.  
Specimen Preparation
Separate serum or plasma from cells. Transfer 1 mL serum, plasma or CSF to a sterile container. (Min: 0.5 mL)  
Storage/Transport Temperature
Unacceptable Conditions
Whole blood (refer to Epstein-Barr Virus, Quantitative PCR, Whole Blood, ARUP test code 0051353). Heparinized specimens.  
Specimen source required.  
Ambient: 24 hours; Refrigerated: 5 days; Frozen: 1 year.  
Reference Interval
Not detected
Interpretive Data
The quantitative range of this assay is 2.6-7.6 log copies/mL (390-39,000,000 copies/mL)

A negative result (less than 2.6 log copies/mL or less than 390 copies/mL) does not rule out the presence of PCR inhibitors in the patient specimen, or EBV DNA nucleic acid in concentrations below the level of detection of the assay. Inhibition may also lead to underestimation of viral quantitation.

No international standard is currently available for calibration of this assay. Caution should be taken when interpreting results generated by different assay methodologies.

Compliance Statement A: For laboratory developed tests using a manufacturer labeled ASR as the reagent providing the specificity of the assay. Analyte Specific Reagent. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, the FDA has determined that such clearance or approval is not necessary.
The limit of quantification for this DNA assay is 2.6 log copies/mL (390 copies/mL). If the assay DID NOT DETECT the virus, the test result will be reported as "<2.6 log copies/mL (<390 copies/mL)." If the assay DETECTED the presence of the virus but was not able to accurately quantify the number of copies, the test result will be reported as "Not Quantified."
CPT Code(s)
Component Test Code*Component Chart NameLOINC
0051338Epstein-Barr Virus, Quant. Source31208-2
0051351Epstein-Barr Virus, Quant. Log53774-6
0051821Epstein-Barr Virus, Quant. Interp5005-4
2002318Epstein-Barr Virus, Quant. Copy/mL32585-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • EBV
  • EBV Quant PCR
  • EBV quantitative
  • herpes
  • HHV-4
  • Human herpesvirus 4
  • Viral load monitoring