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Prothrombin Antibody, IgM
0051303
Ordering Recommendation
Preferred second-line testing for strong suspicion of seronegative antiphospholipid syndrome (APS). Order incrementally or concurrently with other non-criteria antiphospholipid antibody tests.
Mnemonic
PROTHROM M
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Mon
Reported
1-8 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Serum separator tube or lt. blue (sodium citrate).  
Specimen Preparation
Transfer 0.5 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.3 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Hemolyzed or lipemic specimens.  
Remarks
 
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year  
Reference Interval
Less than 20.0 Units
Interpretive Data
IgM antibodies to prothrombin may be a risk factor for either venous or arterial thrombosis in antiphospholipid syndrome (APS). Strong clinical correlation is recommended in the absence of lupus anticoagulant, IgG/and/or IgM cardiolipin and/or beta2 glycoprotein antibodies.

If results are positive, repeat testing with two or more specimens drawn at least 12 weeks apart to demonstrate persistence of antibodies.

Results should not be used alone for diagnosis and must be interpreted in light of APS-specific clinical manifestations and/or other criteria phospholipid antibody tests.


Note
CPT Code(s)
86849
Components
Component Test Code*Component Chart NameLOINC
0051303Prothrombin Antibody, IgM40596-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Prothrombin IgA