Rheumatoid Factors, IgA, IgG, and IgM by ELISA
Ordering Recommendation
May aid in prognostication for rheumatoid arthritis. Rheumatoid Arthritis Panel (2003277) is preferred for the workup of suspected rheumatoid arthritis or undifferentiated inflammatory arthritides.
Submit With Order
Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Quantitative Enzyme-Linked Immunosorbent Assay.
Mon, Wed, Fri
1-4 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Serum separator tube.  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)  
Storage/Transport Temperature
Unacceptable Conditions
Contaminated, hemolyzed, icteric, or lipemic specimens.  
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)  
Reference Interval
Test Number Components Reference Interval
Rheumatoid Factor, IgG by ELISA 6 Units or less
Rheumatoid Factor, IgM by ELISA 6 Units or less
Rheumatoid Factor, IgA by ELISA 6 Units or less
Interpretive Data
The presence of all three rheumatoid factor (RF) isotypes at abnormal levels has high specificity for a diagnosis of rheumatoid arthritis (RA). However, the presence of RF isotypes in any combination may be found in a variety of conditions, including Sjogren syndrome and hepatitis infections.
CPT Code(s)
83516 x2; 86431
Component Test Code*Component Chart Name
0051299Rheumatoid Factor, IgG by ELISA
0051300Rheumatoid Factor, IgM by ELISA
0051301Rheumatoid Factor, IgA by ELISA
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Cross References
  • RF Abs
  • RF IgA IgG IgM
  • RF Isotypes
  • RF3