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Cardiolipin Antibodies, IgG, IgM, and IgA
0051162
Ordering Recommendation
Not a recommended panel for the diagnosis of antiphospholipid syndrome (APS). The combined IgG and IgM cardiolipin (aCL) test (0099344) is preferred.
Mnemonic
CARD PAN
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Sun-Sat
Reported
Within 24 hours
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Serum separator tube.  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Plasma or other body fluids. Contaminated, heat-inactivated, hemolyzed, or lipemic specimens.  
Remarks
 
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year  
Reference Interval
Test Number
Components
Reference Interval
0050901Cardiolipin Antibody, IgGEffective August 18, 2014
0-14 GPL: Negative
15-19 GPL: Indeterminate
20-80 GPL: Low to Moderately Positive
81 GPL or above: High Positive
0050902Cardiolipin Antibody, IgMEffective August 18, 2014
0-12 MPL: Negative
13-19 MPL: Indeterminate
20-80 MPL: Low to Moderately Positive
81 MPL or above: High Positive
0098358Cardiolipin Antibody, IgAEffective August 18, 2014
0-11 APL: Negative
12-19 APL: Indeterminate
20-80 APL: Low to Moderately Positive
81 APL or above: High Positive

Interpretive Data
The persistent presence of IgG and/or IgM cardiolipin (CL) antibodies in moderate or high levels (greater than 40 GPL and/or greater than 40 MPL units or greater than 99th percentile) is a laboratory criterion for the diagnosis of antiphospholipid syndrome (APS). Persistence is defined as moderate or high levels of IgG and/or IgM CL antibodies detected in two or more specimens drawn at least 12 weeks apart (J Throm Haemost. 2006;4:295-306). Lower positive levels of IgG and/or IgM CL antibodies (above cutoff but less than 40 GPL and/or less than 40 MPL units) may occur in patients with the clinical symptoms of APS; therefore, the actual significance of these levels is undefined. Results should not be used alone for diagnosis and must be interpreted in light of APS-specific clinical manifestations and/or other criteria phospholipid antibody tests.


Note
CPT Code(s)
86147 x3
Components
Component Test Code*Component Chart NameLOINC
0050901Cardiolipin Antibody IgG3181-5
0050902Cardiolipin Antibody IgM3182-3
0098358Cardiolipin Antibody IgA5076-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • ACA
  • aCL Antibodies
  • aCL Antibody
  • Anticardiolipin Antibodies
  • Cardiolip
  • Cardiolipin Antibodies, IgA, IgG, IgM