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Neuronal Nuclear Antibody (ANNA) Titer IgG by IFA, Serum (INACTIVE as of 5/20/13.  Refer to 2007961)
0050912
Ordering Recommendation
Mnemonic
ANNAGIFA
Methodology
Semi-Quantitative Indirect Fluorescent Antibody
Performed
Wed
Reported
1-9 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Serum separator tube. 
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.15 mL) 
Storage/Transport Temperature
Frozen. 
Unacceptable Conditions
Contaminated, heat-inactivated, hemolyzed, or severely lipemic specimens. 
Remarks
 
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles) 
Reference Interval
< 1:10 No antibody detected.
Interpretive Data
A titer of greater than or equal to 1:10 indicates antibody was detected to either ANNA-1 (anti-Hu) or ANNA-2 (anti-Ri). Animmunoblot assay should be completed for confirmation of ANNA-1 or ANNA-2.

Compliance Statement D: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
Titers of greater than or equal to 1:10 indicate antibody was detected to either ANNA-1 (anti-Hu) or ANNA-2 (anti-Ri) and will be titered to endpoint.  This test is used primarily for titering patient sera that have previously been confirmed as positive for either ANNA-1 or ANNA-2 by immunoblot.  Only an immunoblot can differentiate between ANNA-1 and ANNA-2.
CPT Code(s)
86256
Components
Component Test Code*Component Chart NameLOINC
0050912ANNA Antibody Titer IgG By IFA44770-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases