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Phosphatidylserine Antibodies, IgG, IgM, and IgA
0050905
Ordering Recommendation
Not a recommended panel for the diagnosis of antiphospholipid syndrome (APS). The combined IgG and IgM Phosphatidylserine test is the preferred second-line testing in seronegative APS.
Mnemonic
PHOS AB
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Sun, Tue, Wed, Fri, Sat
Reported
1-3 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Serum separator tube.  
Specimen Preparation
Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.25 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Contaminated, heat-inactivated, hemolyzed, or severely lipemic specimens.  
Remarks
 
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)  
Reference Interval
Test Number
Components
Reference Interval
 Phosphatidylserine Antibody, IgGLess than 11 U/mL
 Phosphatidylserine Antibody, IgMLess than  25 U/mL
 Phosphatidylserine Antibody, IgALess than  20 U/mL


Interpretive Data
IgG and/or IgM antibodies to phosphatidylserine (aPS) may be associated with a positive test for anti-cardiolipin autoantibodies (aCL) and risk for obstetric antiphospholipid syndrome (APS). Strong clinical correlation is recommended in the absence of lupus anticoagulant, IgG and/or IgM cardiolipin and/or beta2 glycoprotein antibodies.

Isolated presence of IgM or IgG antibodies to aPS may have questionable clinical significance for APS and/or SLE.

If results are positive, repeat testing with two or more specimens drawn at least 12 weeks apart to demonstrate persistence of antibodies.

Results should not be used alone for diagnosis and must be interpreted in light of APS-specific clinical manifestations and/or other criteria phospholipid antibody tests.


Note
CPT Code(s)
86148 x3
Components
Component Test Code*Component Chart NameLOINC
0050906Phosphatidylserine Antibody IgG32032-5
0050907Phosphatidylserine Antibody IgM32033-3
0050908Phosphatidylserine Antibody IgA32031-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Anti-Phosphatidylserine
  • Antiphosphatidylserine
  • aPS Antibodies
  • aPS Antibodies IgG, IgM, IgA