Cardiolipin Antibody, IgG
Ordering Recommendation
New York DOH Approval Status
Specimen Required
Serum separator tube.
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)
Refrigerated.
Plasma or other body fluids. Contaminated, heat-inactivated, hemolyzed, or lipemic specimens.
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Sun-Sat
Reported
1-2 days
Reference Interval
Test Number |
Components |
Reference Interval |
---|---|---|
Cardiolipin Antibody IgG | 14 GPL or less |
Interpretive Data
The persistent presence of IgG and/or IgM cardiolipin (CL) antibodies in moderate or high levels (greater than 40 GPL and/or greater than 40 MPL units) is a laboratory criterion for the diagnosis of antiphospholipid syndrome (APS). Persistence is defined as moderate or high levels of IgG and/or IgM CL antibodies detected in two or more specimens drawn at least 12 weeks apart (J Throm Haemost. 2006;4:295-306). Lower positive levels of IgG and/or IgM CL antibodies (above cutoff but less than 40 GPL and/or less than 40 MPL units) may occur in patients with the clinical symptoms of APS; therefore, the actual significance of these levels is undefined. Results should not be used alone for diagnosis and must be interpreted in light of APS-specific clinical manifestations and/or other criteria phospholipid antibody tests.
Component |
Interpretation |
---|---|
Cardiolipin Antibody, IgG | 14 GPL or less Negative 15-19 GPL Indeterminate 20-80 GPL Low to Moderately Positive 81 GPL or greater High Positive |
FDA
Note
GPL = IgG phospholipid units
Hotline History
Hotline History
CPT Codes
86147
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0050901 | Cardiolipin Antibody IgG | 3181-5 |
Aliases
- ACA
- aCL
- aCL Antibody
- aCL IgG
- Anti-Cardiolipin
- Anticardiolipin
- Anticardiolipin Antibodies
- Cardiolip