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Histone Antibody, IgG
0050860
Ordering Recommendation
Evaluate suspected drug-induced lupus. Negative results do not rule out drug-induced lupus.
Mnemonic
AHA
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Mon, Wed-Sat
Reported
1-3 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Serum separator tube.  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Plasma or urine. Contaminated specimens. Grossly hemolyzed, icteric, or lipemic specimens.  
Remarks
 
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)  
Reference Interval
Effective May 16, 2011
0.9 units or lessNegative
1.0-1.5 unitsWeak Positive
1.6-2.5 unitsModerate Positive
2.6 units or greaterStrong Positive

Interpretive Data


Note
Histone antibodies are present in 20-55% of idiopathic systemic lupus erythematosus (SLE) and 80-95% of drug-induced SLE. They occur in less than 20% of other types of connective tissue diseases.
CPT Code(s)
83516
Components
Component Test Code*Component Chart NameLOINC
0050860Histone Antibody, IgG29996-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • AHA IgG, AHA
  • Anti-Histone Antibodies
  • Antihistone Antibodies
  • Histone IgG