Histone Antibody, IgG
0050860
Ordering Recommendation
 
Mnemonic
AHA
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Mon, Wed-Sat
Reported
1-3 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Serum separator tube.  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Plasma or urine. Contaminated specimens. Grossly hemolyzed, icteric, or lipemic specimens.  
Remarks
  
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)  
Reference Interval
Effective May 16, 2011
 
0.9 units or less Negative
1.0-​1.5 units Weak Positive
1.6-​2.5 units Moderate Positive
2.6 units or greater Strong Positive
Interpretive Data
 
Note
Histone antibodies are present in 20-55% of idiopathic systemic lupus erythematosus (SLE) and 80-95% of drug-induced SLE. They occur in less than 20% of other types of connective tissue diseases.
CPT Code(s)
83516
Components
Component Test Code*Component Chart Name
0050860Histone Antibody, IgG
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • AHA IgG, AHA
  • Anti-Histone Antibodies
  • Antihistone Antibodies
  • Histone IgG