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Treponema pallidum Antibody by TP-PA
0050777
Ordering Recommendation
CDC recommended confirmatory test for syphilis. Order if initial screening (eg, RPR, VDRL) is reactive.
Mnemonic
MHA
Methodology
Semi-Quantitative Particle Agglutination
Performed
Mon-Fri
Reported
1-4 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Serum separator tube or plasma separator tube.  
Specimen Preparation
Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.1 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
CSF or other body fluids.  
Remarks
 
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)  
Reference Interval
Nonreactive
Interpretive Data


Note
TP-PA is a helpful diagnostic aid for the patient with a reactive reagin test, but presents with atypical signs of primary, secondary, or late syphilis. TP-PA compares favorably with the FTA test, but appears slightly less sensitive in cases of untreated early primary syphilis. In late syphilis, the agreement with FTA is 99%.

VDRL is the preferred test for cerebrospinal fluid. Treponemal tests (TP-PA or FTA) are not recommended for CSF.  FTAs on CSF may be tested, but TP-PA cannot be tested on CSF.
CPT Code(s)
86780
Components
Component Test Code*Component Chart NameLOINC
0050777Treponema pallidum Ab by TP-PA24312-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • MHA-TP
  • Syphilis Antibody by MHA
  • Syphilis TPPA
  • T pallidum TPPA
  • T. pallidum Antibody by MHA
  • TP-PA
  • Treponema Pallidum AB, Particle Agglutination
  • Treponema pallidum Particle Agglutination Assay