Coccidioides Antibodies Panel, CSF by CF, ID, ELISA
0050710
Ordering Recommendation
Submit With Order
Mnemonic
COCCI CSF
Methodology
Semi-Quantitative Complement Fixation/Qualitative Immunodiffusion/Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Refer to individual components
Reported
2-5 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
 
Collect
CSF.  
Specimen Preparation
Transfer two 1 mL aliquots of CSF to individual ARUP Standard Transport Tubes. (Min: 0.3 mL per aliquot)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Grossly bloody or hemolyzed specimens.  
Remarks
 
Stability
Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)  
Reference Interval
Test Number Components Reference Interval
0050170Coccidioides Antibody by CF Less than 1:2
0050183Coccidioides immitis Antibodies by Immunodiffusion None detected.
0050179Coccidioides Antibody, IgG by ELISA 0.9 IV or less: Negative-​ No significant level of Coccidioides IgG antibody detected.
1.0-​1.4 IV: Equivocal -​ Questionable presence of Coccidioides IgG antibody detected. Repeat testing in 10-​14 days may be helpful.
1.5 IV or greater: Positive -​ Presence of IgG antibody to Coccidioides detected, suggestive of current or past infection.
0050178Coccidioides Antibody, IgM by ELISA 0.9 IV or less: Negative -​ No significant level of Coccidioides IgM antibody detected.
1.0-​1.4 IV: Equivocal -​ Questionable presence of Coccidioides IgM antibody detected. Repeat testing in 10-​14 days may be helpful.
1.5 IV or greater: Positive -​ Presence of IgM antibody to Coccidioides detected, suggestive of current or recent infection.
Interpretive Data
Refer to individual components.
Note
Antibody in CSF is considered diagnostic for coccidioidal meningitis, although 10% of patients with coccidioidal meningitis will not have antibody in CSF. Negative fungal serology does not rule out the possibility of current infection.
CPT Code(s)
86635 x4
Components
Component Test Code*Component Chart Name
0050178Coccidioides Antibody, IgM by ELISA
0050179Coccidioides Antibody, IgG by ELISA
0050183Coccidioides immitis Abs, Precipitin
0050711Coccidioides Ab by CF, CSF
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Cross References
  • Cocci Antibodies Panel
  • COCCI CF,ID,ELISA CSF Coccidioides Antibodies, Spinal Fluid
  • Cocci CSF antibodies panel
  • San Joaquin Fever Antibodies
  • Valley Fever Antibodies