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Extractable Nuclear Antigen Antibodies (RNP, Smith, SSA 52, SSA 60, and SSB)
0050652
Ordering Recommendation
 
Mnemonic
ENA ABS4
Methodology
Semi-Quantitative Multiplex Bead Assay
Performed
Sun-Sat
Reported
1-2 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Serum separator tube.  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)  
Storage/Transport Temperature
Refrigerated..  
Unacceptable Conditions
Plasma or other body fluids. Bacterially contaminated or severely lipemic specimens.  
Remarks
  
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)  
Reference Interval
Effective May 18, 2015
 
Test Number Components Reference Interval
0050470RNP (U1) (Ribonucleic Protein) (ENA) Antibody, IgG 29 AU/mL or less: Negative
30-​40 AU/mL: Equivocal
41 AU/mL or greater: Positive
0050085Smith (ENA) Antibody, IgG 29 AU/mL or less: Negative
30-​40 AU/mL: Equivocal
41 AU/mL or greater: Positive
2012074SSA 52 and 60 (Ro) (ENA) Antibodies, IgG  
 
Components Reference Interval
SSA 52 (Ro) (ENA) Antibody, IgG 29 AU/mL or less: Negative
30-​40 AU/mL: Equivocal
41 AU/mL or greater: Positive
SSA 60 (Ro) (ENA) Antibody, IgG 29 AU/mL or less: Negative
30-​40 AU/mL: Equivocal
41 AU/mL or greater: Positive
0050692SSB (La) (ENA) Antibody, IgG 29 AU/mL or less: Negative
30-​40 AU/mL: Equivocal
41 AU/mL or greater: Positive
Interpretive Data
 
Note
 
CPT Code(s)
86235 x5
Components
Component Test Code*Component Chart NameLOINC
0050085Smith (ENA) Antibody, IgG18323-6
0050470Ribonucleic Protein (U1) (ENA) Ab, IgG38369-5
0050691SSA 52 (Ro) (ENA) Antibody, IgG31625-7
0050692SSB (La) (ENA) Antibody, IgG29965-1
2012055SSA 60 (Ro) (ENA) Antibody, IgG 
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Anti-ENA Anti-Ribonuclear Protein
  • Anti-RNP
  • Anti-Sm IgG
  • Anti-U1 RNP
  • Antibodies to Extractable Nuclear Antigens
  • Ribonucleoprotein Autoantibodies
  • RNP (Anti-RNP)
  • RNP (U1) (Ribonucleic Protein) (ENA) Antibody, IgG
  • Ro Ab
  • Scl 70 Antibodies
  • Smith (ENA) Antibody, IgG
  • Smith Antigen
  • Smith Autoantibodies
  • SmRNP Autoantibodies
  • SSA (Ro) (ENA) Antibody, IgG
    Anti-SSA
  • SSA Ro
  • SSB (La) (ENA) Antibody, IgG
    Anti-SSB
  • SSB LA
  • U1 RNP Ab