In laboratory testing to confirm a diagnosis of a β-thalassemia trait diagnosis, Hb A2
levels should be considered in conjunction with family history and additional laboratory data, including serum iron and iron binding capacity, red cell morphology, hemoglobin, hematocrit, and mean corpuscular volume (MCV).
Patients with a combination of iron deficiency and β-thalassemia may have a normal A2
level. In these cases, elevated A2
level cannot be used to screen for β-thalassemia in these cases.
||Hb A2 Level
||Hb F Level
||Normal or Increased
||Less than 1.5%