Gastric Parietal Cell Antibody, IgG
0050596
Ordering Recommendation
 
Mnemonic
PCA
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Mon, Wed-Sat
Reported
1-3 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Serum separator tube.  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.25 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Urine or plasma. Contaminated, heat-inactivated, grossly hemolyzed, or severely lipemic specimens.  
Remarks
  
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)  
Reference Interval
 
 
0.0-​20.0 Units Negative
20.1-​24.9 Units Equivocal
25.0 Units or greater Positive
Interpretive Data
In the context of vitamin B12 deficiency, the presence of gastric parietal cell antibodies (PCA) and/or intrinsic factor antibodies in association with macrocytic anemia is considered diagnostic for pernicious anemia (PA). However, the presence of gastric PCAs alone is not specific for PA. Gastric PCAs may occur with increased frequency in unaffected family members, a small percentage of healthy individuals, and patients with other autoimmune diseases, such as autoimmune thyroiditis.  
Note
Most patients with pernicious anemia have parietal cell antibodies. However, the fact that such antibodies are found with increased frequency in unaffected family members, as well as in patients with other autoimmune diseases, suggests these antibodies do not cause disease by themselves.
CPT Code(s)
83516
Components
Component Test Code*Component Chart Name
0050596Gastric Parietal Cell Antibody, IgG
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Aliases
  • Anti-GPA (AGPA)
  • Anti-Parietal Cell Antibody (APCA)
  • Hydrogen Potassium (H+/K+) ATPase
  • Parietal Cell Ab, IgG
  • PCA
  • PCA IgG