Gastric Parietal Cell Antibody, IgG
Ordering Recommendation

Recommended for the evaluation of pernicious anemia or immune-mediated deficiency of vitamin B12 with or without megaloblastic anemia. Negative results do not rule out pernicious anemia.

Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Mon, Wed-Sat
1-3 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Serum separator tube. 
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.25 mL) 
Storage/Transport Temperature
Unacceptable Conditions
Urine or plasma. Contaminated, heat-inactivated, grossly hemolyzed, or severely lipemic specimens. 
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles) 
Reference Interval
0.0-20.0 UnitsNegative
20.1-24.9 UnitsEquivocal
25.0 Units or greaterPositive

Interpretive Data
In the context of vitamin B12 deficiency, the presence of gastric parietal cell antibodies (PCA) and/or intrinsic factor antibodies in association with macrocytic anemia is considered diagnostic for pernicious anemia (PA). However, the presence of gastric PCAs alone is not specific for PA. Gastric PCAs may occur with increased frequency in unaffected family members, a small percentage of healthy individuals, and patients with other autoimmune diseases, such as autoimmune thyroiditis.

Most patients with pernicious anemia have parietal cell antibodies. However, the fact that such antibodies are found with increased frequency in unaffected family members, as well as in patients with other autoimmune diseases, suggests these antibodies do not cause disease by themselves.
Hotline History
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Component Test Code*Component Chart NameLOINC
0050596Gastric Parietal Cell Antibody, IgG40960-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Anti-GPA (AGPA)
  • Anti-Parietal Cell Antibody (APCA)
  • Hydrogen Potassium (H+/K+) ATPase
  • Parietal Cell Ab, IgG
  • PCA
  • PCA IgG