Immunoglobulin G Subclasses (1, 2, 3, 4)
0050577
Ordering Recommendation
Do not order for total IgG measurements. Secondary test in suspected immunoglobulin deficiency. Do not order before IgG, IgA, and IgM measurements are performed.
Mnemonic
IGG SUB
Methodology
Quantitative Nephelometry
Performed
Mon-Sat
Reported
1-3 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Serum separator tube or green (sodium or lithium heparin).  
Specimen Preparation
Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 2 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.45 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
  
Remarks
  
Stability
After separation from cells: Ambient: 2 hours; Refrigerated: 8 days; Frozen: 6 months  
Reference Interval
                                                           
 
Test Number Components Reference Interval
0050571Immunoglobulin G Subclass 1 Cord blood: 435-​1084 mg/dL                5-​6 years: 330-​1065 mg/dL
0-​2 months: 218-​498 mg/dL                  7-​8 years: 225-​1100 mg/dL
3-​5 months: 143-​394 mg/dL                  9-​10 years: 390-​1235 mg/dL
6-​8 months: 190-​388 mg/dL                  11-​12 years: 380-​1420 mg/dL
9-​23 months: 288-​880 mg/dL                13-​14 years: 165-​1440 mg/dL
2 years: 170-​950 mg/dL                          15 years and older: 240-​1118 mg/dL
3-​4 years: 290-​1065 mg/dL
0050572Immunoglobulin G Subclass 2 Cord blood: 143-​453 mg/dL                  5-​6 years: 57-​345 mg/dL
0-​2 months: 40-​167 mg/dL                    7-​8 years: 42-​375 mg/dL
3-​5 months: 23-​147 mg/dL                    9-​10 years: 61-​430 mg/dL
6-​8 months: 37-​60 mg/dL                      11-​12 years: 73-​455 mg/dL
9-​23 months: 30-​327 mg/dL                  13-​14 years: 71-​460 mg/dL
2 years: 22-​440 mg/dL                            15 years and older: 124-​549 mg/dL
3-​4 years: 28-​315 mg/dL
0050573Immunoglobulin G Subclass 3 Cord blood: 27-​146 mg/dL                    5-​6 years: 8-​126 mg/dL
0-​2 months: 4-​23 mg/dL                        7-​8 years: 9-​107 mg/dL
3-​5 months: 4-​70 mg/dL                        9-​10 years: 10-​98 mg/dL
6-​8 months: 12-​62 mg/dL                      11-​12 years: 16-​194 mg/dL
9-​23 months: 13-​82 mg/dL                    13-​14 years: 12-​178 mg/dL
2 years: 4-​69 mg/dL                                15 years and older: 21-​134 mg/dL
3-​4 years: 4-​71 mg/dL
0050576Immunoglobulin G Subclass 4 Cord blood: 1-​47 mg/dL                        5-​6 years: 2-​116 mg/dL
0-​2 months: 1-​33 mg/dL                        7-​8 years: 0-​138 mg/dL
3-​5 months: 1-​14 mg/dL                        9-​10 years: 1-​95 mg/dL
6-​8 months: 1-​16 mg/dL                        11-​12 years: 1-​153 mg/dL
9-​23 months: 1-​65 mg/dL                      13-​14 years: 2-​143 mg/dL
2 years: 0-​120 mg/dL                              15 years and older: 7-​89 mg/dL
3-​4 years: 0-​90 mg/dL
Interpretive Data
The total IgG (mg/dL) can be derived from the sum of the subclass IgG1, IgG2, IgG3, and IgG4 values. However, a confirmatory and more precise total IgG is available by the nephelometric method of quantitation for total IgG. Refer to test Immunoglobulin G, Serum (0050350).  
Note
 
CPT Code(s)
82787 x4
Components
Component Test Code*Component Chart Name
0050571Immunoglobulin G Subclass 1
0050572Immunoglobulin G Subclass 2
0050573Immunoglobulin G Subclass 3
0050576Immunoglobulin G Subclass 4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Gamma-Globulins, Quantitative
  • IgG 1, 2, 3, 4
  • IgG Subclasses
  • Subclasses, IgG