Inflammatory Bowel Disease Differentiation Profile
Ordering Recommendation
Preferred test for differentiating Crohn disease from ulcerative colitis in inflammatory bowel disease.
Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Semi-Quantitative Indirect Fluorescent Antibody
Refer to individual components
1-4 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
Serum separator tube.  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.6 mL)  
Storage/Transport Temperature
Unacceptable Conditions
Contaminated, heat-inactivated, hemolyzed, or severely lipemic specimens.  
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)  
Reference Interval
Available Separately Components Reference Interval
 Saccharomyces cerevisiae Antibody, IgG  20.0 Units or less: Negative
20.1-​24.9 Units: Equivocal
25.0 Units or greater: Positive
 Saccharomyces cerevisiae Antibody, IgA 20.0 Units or less: Negative
20.1-​24.9 Units: Equivocal
25.0 Units or greater: Positive
 Anti-​Neutrophil Cytoplasmic Antibody, Atypical Pattern < 1:20:  Not significant
Interpretive Data
P-ANCA antibodies are found in 50-70% of ulcerative colitis (UC) patients, but in only 20% of Crohn disease (CD) patients. In contrast, Saccharomyces cerevisiae IgG antibodies are found in 80% of CD patients, but only 20% of UC patients. Saccharomyces cerevisiae IgA antibodies are found in 35% of CD patients but<1% in UC patients.  
This test may be a useful tool for distinguishing ulcerative colitis (UC) from Crohn disease (CD) in patients with suspected inflammatory bowel disease.
CPT Code(s)
86671 x2; 86255
Component Test Code*Component Chart NameLOINC
0050562S. cerevisiae Antibody, IgG47321-5
0050563S. cerevisiae Antibody, IgA47320-7
0050812Atypical ANCA49503-6
2003240EER Inflammatory Bowel Disease PRO11526-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • ASCA
  • atypical p-ANCA Ab
  • atypical p-ANCA IgG
  • Atypical perinuclear anticytoplasmic neutrophil Ab
  • Atypical perinuclear anticytoplasmic neutrophil IgG
  • IBD Differentiation Profile
  • S. cerevisiae Ab
  • Saccharomyces cerevisiae Antibody