Inflammatory Bowel Disease Differentiation Profile (INACTIVE as of 07/05/2016: Refer to May 2016 Hot Line for Replacement Test: 2013270, ACTIVE 07/05/16)
Ordering Recommendation
Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Semi-Quantitative Indirect Fluorescent Antibody
Refer to individual components
1-4 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Serum separator tube. 
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.6 mL) 
Storage/Transport Temperature
Unacceptable Conditions
Contaminated, heat-inactivated, hemolyzed, or severely lipemic specimens. 
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles) 
Reference Interval
Available Separately
Reference Interval
 S. cerevisiae Antibody, IgG20.0 Units or less: Negative
20.1-24.9 Units: Equivocal
25.0 Units or greater: Positive
 S. cerevisiae Antibody, IgA20.0 Units or less: Negative
20.1-24.9 Units: Equivocal
25.0 Units or greater: Positive
 Atypical ANCA< 1:20:  Not significant

Interpretive Data
P-ANCA antibodies are found in 50-70% of ulcerative colitis (UC) patients, but in only 20% of Crohn disease (CD) patients. In contrast, Saccharomyces cerevisiae IgG antibodies are found in 80% of CD patients, but only 20% of UC patients. Saccharomyces cerevisiae IgA antibodies are found in 35% of CD patients but<1% in UC patients.

This test may be a useful tool for distinguishing ulcerative colitis (UC) from Crohn disease (CD) in patients with suspected inflammatory bowel disease.
CPT Code(s)
86671 x2; 86255
Component Test Code*Component Chart NameLOINC
0050562S. cerevisiae Antibody, IgG47321-5
0050563S. cerevisiae Antibody, IgA47320-7
0050812Atypical ANCA49503-6
2003240EER Inflammatory Bowel Disease PRO11526-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • ASCA
  • atypical p-ANCA Ab
  • atypical p-ANCA IgG
  • Atypical perinuclear anticytoplasmic neutrophil Ab
  • Atypical perinuclear anticytoplasmic neutrophil IgG
  • IBD Differentiation Profile
  • S. cerevisiae Ab
  • Saccharomyces cerevisiae Antibody